Heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia.
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DOI:
10.1182/asheducation-2013.1.668
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发表时间:
2013
期刊:
影响因子:
--
通讯作者:
Arepally GM
中科院分区:
文献类型:
--
作者:
Lee GM;Arepally GM
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder caused by antibodies that recognize complexes of platelet factor 4 (PF4) and heparin. HIT is frequently considered in the differential diagnosis of thrombocytopenia occurring in patients on heparin therapy. HIT is a challenging diagnosis because of routine heparin use in hospitalized patients, the common occurrence of thrombocytopenia, and high rates of anti-PF4/heparin seroconversions in patients treated with heparin. This chapter will summarize our diagnostic approach to HIT by underscoring critical elements of the clinical and laboratory evaluation.
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