Non-allergic rhinitis with eosinophils and mast cells constitutes a new severe nasal disorder
Non-allergic rhinitis with eosinophils and mast cells constitutes a new severe nasal disorder
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DOI：
10.1177/039463200802100209
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发表时间：
2008-04-01
影响因子：
3.5
通讯作者：
Ciprandi, G.
中科院分区：
文献类型：
--
作者：
Gelardi, M.;Del Giudice, A. Maselli;Ciprandi, G.
炎症性非过敏性鼻炎（NAR）主要有三种类型：嗜酸性粒细胞（NARES）浸润的NAR，肥大细胞（NARMA）浸润的NAR，中性粒细胞（NARNE）浸润的NAR。一种新的特殊类型以嗜酸性粒细胞和肥大细胞浸润为特征（NARESMA）。本研究的目的是评估NARES、NARMA、NARNE和NARESMA患者的临床和功能特征，并对后者进行定义。对176例NAR患者进行前瞻性和连续性评估：52例NARES患者，38例NARMA患者，36例NARNE患者，50例NARESMA患者。评估两组患者的临床特征、生活质量（QoL）及鼻压测量指标。四组患者生活质量差异有统计学意义。NARESMA患者的生活质量最差。NARESMA患者鼻功能与生活质量显著相关。NARESMA患者鼻息肉和哮喘均有显著相关性。本研究首次证明NARESMA是一种新型的NAR，是一种特别严重的疾病。
Three main types of inflammatory Non-Allergic Rhinitis (NAR) have been defined: NAR infiltrated by eosinophils (NARES), by mast cells (NARMA), and by neutrophils (NARNE). A new particular type has been characterized with current infiltration by eosinophils and mast cells (NARESMA). The aim of this study is to evaluate the clinical and functional characteristics in patients with NARES, NARMA, NARNE, and NARESMA and to define the latter. One hundred and seventy-six NAR patients were prospectively and consecutively evaluated: 52 patients with NARES, 38 with NARMA, 36 with NARNE, and 50 with NARESMA. Clinical features, Quality of Life (QoL), and rhinomanometry were evaluated in all of them. QoL was significantly different in the 4 groups. NARESMA patients had the worst QoL. Nasal function and QoL in NARESMA patients were significantly correlated. Significant associations were shown with both nasal polyps and asthma in NARESMA patients. This study provides the first evidence that NARESMA constitutes a new type of NAR and is a particularly severe disorder.