Development of Novel Microenvironments for Promoting Enhanced Wound Healing
Development of Novel Microenvironments for Promoting Enhanced Wound Healing
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DOI：
10.1007/s43152-020-00009-6
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
G. Scull;Ashley C. Brown
中科院分区：
文献类型：
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作者：
G. Scull;Ashley C. Brown
审查目的不愈合的伤口是医疗保健行业面临的一个重大问题。调节伤口微环境的材料具有改善愈合结果的潜力。最新发现已经开发出多种用于调节伤口微环境的非细胞和细胞支架，包括用于控制释放抗菌剂和生长因子的材料、具有固有免疫调节特性的材料以及新型胶体支架。支架构建方法包括静电纺丝、3D 打印、细胞外基质脱细胞或技术组合。材料应用方法包括在伤口部位分层或注射。总结虽然这些技术显示出修复伤口的前景，但迄今为止所有材料策略都难以诱导汗腺和毛囊等特征的再生。尽管如此，目前处于研究阶段的创新技术可能有助于未来实现这些功能。新的方法和材料不断出现，用于开发促进伤口愈合的微环境。
Purpose of ReviewNon-healing wounds are a significant issue facing the healthcare industry. Materials that modulate the wound microenvironment have the potential to improve healing outcomes.Recent FindingsA variety of acellular and cellular scaffolds have been developed for regulating the wound microenvironment, including materials for controlled release of antimicrobials and growth factors, materials with inherent immunomodulative properties, and novel colloidal-based scaffolds. Scaffold construction methods include electrospinning, 3D printing, decellularization of the extracellular matrix, or a combination of techniques. Material application methods include layering or injecting at the wound site.SummaryThough these techniques show promise for repairing wounds, all material strategies thus far struggle to induce regeneration of features such as sweat glands and hair follicles. Nonetheless, innovative technologies currently in the research phase may facilitate future attainment of these features. Novel methods and materials are constantly arising for the development of microenvironments for enhanced wound healing.