A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia
A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia
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慢性粒细胞白血病并发原发性胃弥漫性大B细胞淋巴瘤1例
DOI：
10.2147/ott.s212838
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Ge, Zheng
中科院分区：
文献类型：
--
作者：
Cai, Zhimei;Liu, Shuo;Ge, Zheng
摘要慢性粒细胞白血病（CML）和非霍奇金淋巴瘤（NHL）是两种不同起源的血液系统恶性肿瘤，二者很少同时发生。此外，NHL继发于CML是常见的T细胞淋巴瘤，而B细胞起源的NHL是罕见的。自1999年以来，仅报道了22例B细胞淋巴瘤，其中4例为弥漫性大B细胞淋巴瘤（DLBCL）。弥漫性大B细胞淋巴结淋巴结、肝脏、空肠、软腭。据我们所知，在CML中发生原发性胃DLBCL（PG-DLBCL）尚未见报道。在这里，我们报告了一个63岁的男子慢性期（CP）慢性粒细胞白血病与PG-DLBCL。患者于近8年前被诊断为CML，先后接受伊马替尼和尼洛替尼治疗。但2018年3月胃镜检查发现患者胃内恶性病变，肿块诊断为PG-DLBCL。随后，患者接受RCOP +来那度胺方案化疗3个周期，达到近完全缓解（CR）。
Abstract Chronic myeloid leukemia (CML) and Non-Hodgkin Lymphoma (NHL) are two different origins of hematological malignancies, which rarely occur at the same time. Moreover, NHL secondary to CML is common in T cell lymphoma, while NHL of B cell origin is rare. Since 1999, only 22 cases with B cell lymphoma have been reported, of which 4 cases have diffuse large B-cell lymphoma (DLBCL). The lesions of DLBCL were in lymph node, liver, jejunum, and soft palate. To our knowledge, it has no report for the primary gastric DLBCL (PG-DLBCL) occurring in CML. Here we reported a 63-year-old man of chronic phase (CP) CML associated with PG-DLBCL. The patient was diagnosed with CML nearly eight years ago and was treated with imatinib and nilotinib successively. However, gastroscopy found malignant lesions in the patient’s stomach in March 2018, and the masses were diagnosed as PG-DLBCL. Subsequently, with the treatment of the RCOP + lenalidomide regimen chemotherapy for 3 cycles, the patient achieved nearly complete remission (CR).