Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency: Relation to postprandial dyslipidemia
Peripheral inflammatory and fibrinolytic markers in adolescents with growth hormone deficiency: Relation to postprandial dyslipidemia
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DOI：
10.1016/j.jpeds.2004.07.037
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Palacios, A
中科院分区：
文献类型：
--
作者：
Lanes, R;Paoli, M;Palacios, A
目的为了确定是否外周炎症和纤溶标志物升高生长激素缺乏（GHD）的青少年和相关的餐后lipoprotein.Study设计15 GHD儿童生长激素治疗的时间年龄为12.7 +/- 2.5年和10个未经治疗的GHD青少年的时间年龄为13.0 +/- 2.6年进行了研究。分别于空腹及进食高脂餐后4 h测定甘油三酯（TG）、C反应蛋白（CRP）、纤维蛋白原、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α），并与15名健康青少年作对照。未经治疗的GHD青少年的空腹TNF-α、CRP和纤维蛋白原浓度高于健康对照组，但与GH治疗的GHD青少年相似。尽管GHD青少年在高脂餐后纤维蛋白原水平升高，但CRP、TNF-α和IL-6浓度并未进一步升高。未经治疗的GHD青少年的空腹和餐后TG与空腹和餐后CRP以及餐后TNF-α和IL-6浓度呈正相关。空腹TG也呈正相关，空腹纤维蛋白原浓度在未经治疗和治疗GHD adolescents.Conclusions在GHD青少年的显着的炎症反应似乎与存在的空腹和餐后TG水平升高，这可能会导致过早动脉粥样硬化的易感性增加。
Objective To determine whether peripheral inflammatory and fibrinolytic markers are elevated in growth hormone-deficient (GHD) adolescents and associated with increased postprandial lipoproteins.Study design Fifteen GHD children on GH treatment with a chronologic age of 12.7 +/- 2.5 years and 10 untreated GHD adolescents with a chronologic age of 13.0 +/- 2.6 years were studied. Triglycerides (TG), C-reactive protein (CRP), fibrinogen, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) were measured in the fasting state and 4 hours after ingesting a high-fat meal; 15 healthy adolescents served as controls.Results Fasting and postprandial TG of untreated GHD children were higher than those in treated subjects and healthy controls. Fasting TNF-alpha, CRP, and fibrinogen concentrations of untreated GHD adolescents were higher than those in healthy controls, but similar to those of GH-treated GHD adolescents. Although fibrinogen levels increased after a high-fat meal in GHD adolescents, CRP, TNF-alpha, and IL-6 concentrations did not increase further. Fasting and postprandial TG of untreated GHD adolescents were positively associated with fasting and postprandial CRP, and with postprandial TNF-alpha and IL-6 concentrations. Fasting TG also correlated positively with fasting fibrinogen concentrations in untreated and treated GHD adolescents.Conclusions The pronounced inflammatory response seen in GHD adolescents seems to be associated with the presence of elevated levels of fasting and postprandial TG, which may result in an increased susceptibility for premature atherosclerosis.