β-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors
β-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors
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DOI：
10.1158/0008-5472.can-3627-2
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发表时间：
2004-02-15
期刊：
影响因子：
11.2
通讯作者：
Jung, A
中科院分区：
文献类型：
--
作者：
Hiendlmeyer, E;Regus, S;Jung, A
尿激酶纤溶酶原激活物（uPA）的表达在结直肠肿瘤从腺瘤到癌的进展过程中增加。最高量的uPA被发现在癌的侵袭前沿，其也显示出核β-连环蛋白的强表达，因此是高水平表达β-连环蛋白靶基因的区域。在这里，我们表明，β-连环蛋白有助于uPA的反式激活。因此。β-连环蛋白可能对结肠直肠肿瘤的侵袭和转移以及休眠的能力有影响，这是癌症的标志。
Expression of the urokinase plasminogen activator (uPA) increases during the progression of colorectal tumors from adenomas to carcinomas. The highest amounts of uPA are found at the invasion front of carcinomas, which also displays a strong expression of nuclear beta-catenin and is therefore a region expressing beta-catenin target genes at high levels. Here we show that beta-catenin contributes to the transactivation of uPA. Therefore. beta-catenin might have an impact on the capacity of colorectal tumors for invasion and metastasis, as well as dormancy, which are hallmarks of cancer.