Features of Metabolic Syndrome and Its Associated Factors during Highly Active Antiretroviral Therapy in Ouagadougou (Burkina Faso).
Features of Metabolic Syndrome and Its Associated Factors during Highly Active Antiretroviral Therapy in Ouagadougou (Burkina Faso).
复制标题
DOI：
10.1177/2325957415601503
复制
发表时间：
2016-03-01
影响因子：
--
通讯作者：
Drabo, Joseph Youssouf
中科院分区：
文献类型：
--
作者：
Guira, Oumar;Tieno, Herve;Drabo, Joseph Youssouf
背景：研究瓦加杜古市高效抗逆转录病毒治疗(HAART)中代谢综合征(MS)的特点及其相关因素。对接受抗逆转录病毒药物至少6个月的成年人的非概率样本进行了研究。妊娠、腹水或腹部肿块是非纳入标准。代谢综合征符合2005年国际糖尿病联合会的标准。结果：作者研究了300例患者。代谢综合征54例(18%)，平均年龄44.8±7.4岁，性别比0.17，平均HAART时间71±30.9个月。目前MS的异常为低高密度脂蛋白(HDLc)37例(68.5%)，多见于高腰围+低HDLc+血压异常(29.6%)。相关因素有：应用蛋白水解酶抑制剂(P=.000)、女性(P=.004)、42岁(P=.001)和脂肪营养不良(P=.01)。结论：在护理HIV感染者时应考虑心血管风险。
BACKGROUND: To study the features of metabolic syndrome (MS) and its associated factors during highly active antiretroviral therapy (HAART), in Ouagadougou.METHODS: It was a cross-sectional study from March to November 2011 in Yalgado Ouedraogo hospital. A nonprobability sample of adults receiving antiretroviral drugs for at least 6 months was studied. Pregnancy, ascites, or abdominal mass were noninclusion criteria. Metabolic syndrome met the criteria of International Diabetes Federation 2005.RESULTS: The authors studied 300 patients. Metabolic syndrome was diagnosed in 54 (18%) patients: mean age 44.8 ± 7.4 years, sex ratio 0.17, and mean duration of HAART 71 ± 30.9 months. The current anomaly of MS was low high-density lipoprotein (HDL)-cholesterol in 37 patients (68.5%), and the common profile of MS was high waist circumference + low HDL-cholesterol + abnormal blood pressure (29.6%). Associated factors were protease inhibitor regimens (P = .000), female gender (P = .004), age > 42 years (P = .001), and lipodystrophy (P = .01).CONCLUSION: Cardiovascular risks should be regarded during the care of HIV-infected patients.