Tracing PAKs from GI inflammation to cancer
Tracing PAKs from GI inflammation to cancer
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DOI：
10.1136/gutjnl-2014-306768
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发表时间：
2014-07-01
期刊：
影响因子：
24.5
通讯作者：
Gasche, Christoph
中科院分区：
文献类型：
--
作者：
Dammann, Kyle;Khare, Vineeta;Gasche, Christoph
P-21激活的蛋白激酶(PAK)是rac1/CDc42的效应物，负责协调信号从细胞膜到细胞核的传递。PAK的激活驱动重要的信号通路，包括有丝分裂原激活的蛋白激酶、磷脂酰肌醇3-激酶(PI3K/AKT)、核因子-kappaB和Wnt/β-catenin。肠道PAK1的表达随着炎症和恶变的增加而增加，尽管PAKs在胃肠道疾病的发生和发展中的生物学相关性还不完全清楚。这篇综述强调了改变的PAK激活在胃肠道炎症中的重要性，强调了它对致癌信号的影响，并讨论了PAK作为化学预防的治疗靶点。
P-21 activated kinases (PAKs) are effectors of Rac1/Cdc42 which coordinate signals from the cell membrane to the nucleus. Activation of PAKs drive important signalling pathways including mitogen activated protein kinase, phospoinositide 3-kinase (PI3K/AKT), NF-kappa B and Wnt/beta-catenin. Intestinal PAK1 expression increases with inflammation and malignant transformation, although the biological relevance of PAKs in the development and progression of GI disease is only incompletely understood. This review highlights the importance of altered PAK activation within GI inflammation, emphasises its effect on oncogenic signalling and discusses PAKs as therapeutic targets of chemoprevention.