Molecular Pathways Molecular Pathways : Interleukin-15 Signaling in Health and in Cancer
Molecular Pathways Molecular Pathways : Interleukin-15 Signaling in Health and in Cancer
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发表时间：
2014
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通讯作者：
A. Mishra;Laura A. Sullivan;M. Caligiuri
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作者：
A. Mishra;Laura A. Sullivan;M. Caligiuri
白细胞介素-15（IL-15）是一种促炎细胞因子，通过多种信号通路参与多种淋巴细胞谱系的发育、存活、增殖和活化。IL-15利用至少两种不同组合的三种不同受体链来发出信号并对免疫系统发挥作用。IL-15与其受体复合物的结合激活自然杀伤细胞和T细胞亚群中的“免疫增强”信号级联，以及诱导许多原癌基因。其他研究已经探索了IL-15在癌症的发展和进展中的作用，特别是大颗粒淋巴细胞白血病、皮肤T细胞淋巴瘤和多发性骨髓瘤。本文综述了IL-15信号通路中的分子事件及其与慢性炎症和癌症相关的调节异常。我们简要地探讨了这些研究的结果，以进一步治疗癌症的潜在治疗机会。这些涉及靶向IL-15信号传导的破坏以及IL-15介导的先天性和抗原特异性免疫的增强。临床癌症研究; 20（8）; 2044-50。2014年AACR。披露潜在利益冲突本集团并无披露任何潜在利益冲突。计划委员会成员没有真实的或明显的利益冲突需要披露。
Interleukin-15 (IL-15) is a proinflammatory cytokine involved in the development, survival, proliferation, and activation ofmultiple lymphocyte lineages utilizing a variety of signaling pathways. IL-15 utilizes three distinct receptor chains in at least two different combinations to signal and exert its effects on the immune system. The binding of IL-15 to its receptor complex activates an "immune-enhancing" signaling cascade in natural killer cells and subsets of T cells, as well as the induction of a number of proto-oncogenes. Additional studies have explored the role of IL-15 in the development and progression of cancer, notably leukemia of large granular lymphocytes, cutaneous T-cell lymphoma, and multiple myeloma. This review provides an overview of the molecular events in the IL-15 signaling pathway and the aberrancies in its regulation that are associated with chronic inflammation and cancer. We briefly explore the potential therapeutic opportunities that have arisen as a result of these studies to further the treatment of cancer. These involve both targeting the disruption of IL-15 signaling as well as IL-15–mediated enhancement of innate and antigen-specific immunity. Clin Cancer Res; 20(8); 2044–50. 2014 AACR. Disclosure of Potential Conflicts of Interest No potential conflicts of interest were disclosed. CME Staff Planners' Disclosures The members of the planning committee have no real or apparent conflict of interest to disclose.