Inhaled NO and markers of oxidant injury in infants with respiratory failure.
Inhaled NO and markers of oxidant injury in infants with respiratory failure.
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DOI：
10.1038/sj.jp.7211327
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发表时间：
2005-07-01
期刊：
影响因子：
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通讯作者：
Dennery, Phyllis A
中科院分区：
文献类型：
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作者：
Van Meurs, Krisa P;Cohen, Toby L;Dennery, Phyllis A
背景：吸入一氧化氮（iNO）是治疗婴儿呼吸衰竭的有效辅助手段。虽然有明确的好处，这种疗法，潜在的毒性可能会导致反应性亚硝基化species.OBJECTIVE：要评估是否iNO治疗是与增加血清标志物的氧化stress.DESIGN/METHOD：多个标志物进行了前瞻性评估，在血清中的足月婴儿严重呼吸衰竭与iNO治疗1至72小时。这些进行了比较，患者暴露于大于80%的氧气超过6小时，室内空气controls.Results：暴露24小时后，iNO治疗的婴儿增加了血清脂质过氧化氢（LPO），蛋白质羰基和硝基酪氨酸残留物，以及血清总谷胱甘肽（GSH）含量增加。LPO的增加在24小时达到峰值，并与iNO的累积剂量相关，而其他标志物则不相关。慢性肺疾病（CLD）的存在并没有相关的血清标志物的氧化损伤。结论：在足月儿呼吸衰竭，长期iNO暴露与氧化应激标志物的短暂增加，但这一发现并没有出现预测CLD的发展。
BACKGROUND: Inhaled nitric oxide (iNO) is an effective adjunct in the treatment of infants with respiratory failure. Although there are clear benefits to this therapy, potential toxicity could result from reactive nitrosylated species.OBJECTIVE: To evaluate whether iNO therapy is associated with increased serum markers of oxidative stress.DESIGN/METHOD: Multiple markers were prospectively evaluated in the serum of term infants with severe respiratory failure treated with iNO for 1 to 72 hours. These were compared to those of patients exposed to greater than 80% oxygen for more than 6 hours and room air controls.RESULTS: After 24 hours of exposure, the iNO-treated infants had increased serum lipid hydroperoxides (LPO), protein carbonyls and nitrotyrosine residues as well as increased serum total glutathione (GSH) content. The increase in LPO peaked at 24 hours and correlated with the cumulative dose of iNO whereas other markers did not. The presence of chronic lung disease (CLD) did not correlate with serum markers of oxidative injury.CONCLUSIONS: In term infants with respiratory failure, prolonged iNO exposure is associated with a transient increase in markers of oxidative stress, but this finding does not appear to predict the development of CLD.