Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.
Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.
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环状RNA UBAP2的增加充当miR-143的海绵，促进骨肉瘤进展
DOI：
10.18632/oncotarget.18671
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发表时间：
2017-09-22
期刊：
影响因子：
--
通讯作者：
Ji F
中科院分区：
文献类型：
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作者：
Zhang H;Wang G;Ding C;Liu P;Wang R;Ding W;Tong D;Wu D;Li C;Wei Q;Zhang X;Li D;Liu P;Cui H;Tang H;Ji F
环状RNA（circRNA）的表达失调已被确定在癌症发生和进展中是重要的;然而，在最常见类型的原发性恶性骨肿瘤骨肉瘤中，circRNA在癌症发展中的作用仍有待阐明。在这里，我们发现circRNA UBAP 2（circUBAP 2）的表达显着增加，在人类骨肉瘤组织相比，在匹配的控制。circUBAP 2表达的增加与人骨肉瘤的进展和预后显著相关。此外，在体外和体内，circUBAP 2的增加可以促进骨肉瘤的生长并抑制凋亡。在机制上，发现circUBAP 2抑制microRNA-143（miR-143）的表达，从而增强抗凋亡Bcl-2的表达和功能，Bcl-2是miR-143的直接靶点。总之，我们的研究结果表明circUBAP 2在骨肉瘤发展中的作用，并暗示其在预后预测和癌症治疗中的潜力。
Deregulated expression of circular RNA (circRNA) has been determined to be important in carcinogenesis and progression; however, in the most common type of primary malignant bone tumor osteosarcoma, the roles of circRNA in cancer development still remain to be elucidated. Here, we found that circRNA UBAP2 (circUBAP2) expression is significantly increased in human osteosarcoma tissues as compared to those in matched controls. Increased circUBAP2 expression was significantly correlated with human osteosarcoma progression and prognosis. Furthermore, increased circUBAP2 could promote osteosarcoma growth and inhibit apoptosis both in vitro and in vivo. Mechanistically, circUBAP2 was found to inhibit the expression of microRNA-143 (miR-143), thus enhancing the expression and function of anti-apoptotic Bcl-2, which is a direct target of miR-143. Together, our results suggest the roles of circUBAP2 in osteosarcoma development and implicate its potential in prognosis prediction and cancer therapy.