Causes of fever in adults on the Thai-Myanmar border
Causes of fever in adults on the Thai-Myanmar border
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DOI：
10.4269/ajtmh.2006.74.108
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Miller, RS
中科院分区：
文献类型：
--
作者：
Ellis, RD;Fukuda, MM;Miller, RS
在泰缅边境进行了一项以医院为基础的研究，以更好地了解发热性疾病的原因，并确定可能存在哪些人畜共患和媒介传播的新发传染病。 1999年6月至2002年3月期间共有613名成年人入组。根据临床表现和实验室结果对病例进行分类。 48% 的受试者得到了病因诊断。疟疾是最常见的诊断，占受试者的 25%，其中三分之二是恶性疟原虫。在 17% 的受试者中发现了钩端螺旋体病的血清学证据。其他病因诊断包括立克次体感染、登革热和伤寒。最常见的临床诊断是非特异性发热性疾病、呼吸道感染和胃肠炎。临床关联通常不能预测病因诊断。明显的双重诊断很常见，特别是疟疾和钩端螺旋体病。研究结果已用于修改该地区不明发热性疾病的治疗。
A hospital-based study was conducted along the Thai-Myanmar border to provide greater knowledge of the causes of febrile illness and to determine what zoonotic and vector-borne emerging infectious diseases might be present. A total of 613 adults were enrolled from June 1999 to March 2002. Cases were classified based on clinical findings and laboratory results. An etiologic diagnosis was made for 48% of subjects. Malaria was the most common diagnosis, accounting for 25% of subjects, with two-thirds Plasmodium falciparum. Serologic evidence for leptospirosis was found in 17% of subjects. Other etiologic diagnoses included rickettsial infections, dengue fever, and typhoid. The most frequent clinical diagnoses were nonspecific febrile illness, respiratory infections, and gastroenteritis. Clinical associations were generally not predictive of etiologic diagnosis. Apparent dual diagnoses were common, particularly for malaria and leptospirosis. Findings have been used to modify treatment of unspecified febrile illness in the area.