Comparison of Schistosoma mansoni Prevalence and Intensity of Infection, as Determined by the Circulating Cathodic Antigen Urine Assay or by the Kato-Katz Fecal Assay: A Systematic Review.
Comparison of Schistosoma mansoni Prevalence and Intensity of Infection, as Determined by the Circulating Cathodic Antigen Urine Assay or by the Kato-Katz Fecal Assay: A Systematic Review.
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通过循环的阴极抗原尿液测定法或Kato-katz粪便测定法确定的曼氏菌患病率和感染强度的比较：系统评价。
DOI：
10.4269/ajtmh.15-0725
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Colley DG
中科院分区：
文献类型：
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作者：
Kittur N;Castleman JD;Campbell CH;King CH;Colley DG
Kato-Katz (KK) 粪便显微镜检查结果与曼氏血吸虫感染的基于尿液的护理点循环阴极抗原 (POC-CCA) 检测结果之间的关系仍然是一个关键问题。这篇对 25 篇已发表论文的系统文献综述比较了 KK 和 POC-CCA 检测对曼氏沙门氏菌感染的流行率。十九项已发表的研究符合我们的数据提取和分析纳入标准。 KK 的患病率高于 50%，KK 和 POC-CCA 结果得出的患病率基本相同。 KK 患病率低于 50%，POC-CCA 测定的患病率高出 1.5 至 6 倍，并且随着 KK 患病率下降而增加。九份出版物中有五份符合通过 KK 测定法提取曼氏链球菌感染强度和使用 POC-CCA 测定法提取可见条带密度数据的纳入标准。 KK 和 POC-CCA 测定的强度之间存在明显的正相关关系。该系统评价表明，在低于 50% 的患病率下，POC-CCA 测定比 KK 测定灵敏得多。然而，现有数据不足以精确定义 KK 患病率较低水平下 POC-CCA 与 KK 之间的关系。在低流行地区直接比较这两种检测方法的更多研究对于为国家血吸虫病控制计划的决策提供信息至关重要。
The relationship between results from Kato-Katz (KK) fecal microscopy and urine-based point-of-care circulating cathodic antigen (POC-CCA) assays for Schistosoma mansoni infection remains a critical issue. This systematic literature review of 25 published papers compares prevalence of S. mansoni infection by KK with that by the POC-CCA assay. Nineteen published studies met our inclusion criteria for data extraction and analysis. Above a prevalence of 50% by KK, KK and POC-CCA results yielded essentially the same prevalence. Below 50% prevalence by KK, the prevalence by the POC-CCA assay was between 1.5- and 6-fold higher and increased as prevalence by KK decreased. Five of nine publications met inclusion criteria for extractable data on intensity of S. mansoni infection by KK assay and visual band density using the POC-CCA assay. A clear positive relationship exists between intensity by the KK and POC-CCA assays. This systematic review indicates that below 50% prevalence, the POC-CCA assay is much more sensitive than the KK assay. However, the existing data are inadequate to precisely define the relationship between POC-CCA and KK at lower levels of KK prevalence. More studies directly comparing the two assays in low-prevalence areas are essential to inform decision-making by national schistosomiasis control programs.