Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.
Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.
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DOI：
10.2217/nnm.10.50
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Chilkoti A
中科院分区：
文献类型：
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作者：
MacEwan SR;Callahan DJ;Chilkoti A
纳米粒子和大分子载体已被广泛用于提高化疗药物的疗效，主要是通过增强渗透性和滞留效应提供的被动积累。与游离药物相比，刺激反应肽和聚合物载体可通过三种机制进一步增强抗肿瘤治疗药物的疗效：增加实体瘤内的总体积累；在肿瘤组织中提供均匀的空间分布；增加了抗癌治疗的细胞内定位。本文重点介绍了“智能”刺激反应型多肽、聚合物和脂质药物载体的最新进展，与游离药物相比，这些药物载体旨在提高治疗有效载荷的定位和疗效。
Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in ‘smart’ – stimulus-responsive – peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.