Age at any full-term pregnancy and breast cancer risk
Age at any full-term pregnancy and breast cancer risk
复制标题
DOI：
10.1093/oxfordjournals.aje.a010266
复制
发表时间：
2000-04-01
影响因子：
5
通讯作者：
MacMahon, B
中科院分区：
文献类型：
--
作者：
Chie, WC;Hsieh, CC;MacMahon, B
作者分析了来自两个多州、基于人群的病例对照研究的数据，以调查任何足月妊娠（FP）年龄与乳腺癌风险之间的关系。研究对象包括从1988年至1996年的四个全州癌症登记处确定的20-79岁乳腺癌病例和随机选择的对照组。9，891例病例和12，271例对照组可获得有关乳腺癌综合风险因素的完整信息。大量的受试者能够同时调整协变量和有效应用各种建模方法。总体而言，首次FP时年龄每增加5岁，乳腺癌的比值比为1.07（95%置信区间（CI）：1.01，1.13）。第二至第九次FP时年龄的相应估计值为比值比= 1.02（95% CI：1.00，1.05）。对于末次FP时的年龄，效应估计值（比值比= 1.01，95% CI：0.97，1.06）与首次FP后的其他FP无区别。在这项分析中，还观察到分娩后乳腺癌风险的适度和短暂增加。第一次FP的年龄相对较大的影响与早期第一次FP对乳腺细胞分化的长期影响的存在是一致的，使它们变得不太容易致癌。
The authors analyzed data from two multistate, population-based case-control studies to investigate the association between age at any full-term pregnancy (FP) and breast cancer risk. Study subjects included breast cancer cases aged 20-79 years identified from four statewide cancer registries and randomly selected controls interviewed from 1988 to 1996. Complete information on a comprehensive set of risk factors for breast cancer was available for 9,891 cases and 12,271 controls. The large number of subjects enabled simultaneous adjustment of the covariates and efficient application of various modeling approaches. Overall, each 5-year increase in age at first FP was associated with an odds ratio of 1.07 (95% confidence interval (CI): 1.01, 1.13) for breast cancer. The corresponding estimates were odds ratio = 1.02 (95% CI: 1.00, 1.05) for age at second through ninth FPs. For age at last FP, the effect estimate (odds ratio = 1.01, 95% CI: 0.97, 1.06) was indistinguishable from that for other FPs after the first. In this analysis, a modest and transient increase in breast cancer risk after childbirth was also observed. The relatively greater effect of age at first FP is consistent with the existence of a long-term effect of early first FP on the differentiation of mammary cells, causing them to become less susceptible to carcinogenesis.