ERM proteins in epithelial cell organization and functions
ERM proteins in epithelial cell organization and functions
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DOI：
10.1016/j.bbamcr.2006.06.013
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发表时间：
2007-05-01
影响因子：
5.1
通讯作者：
Arpin, Monique
中科院分区：
文献类型：
--
作者：
Fievet, Bruno;Louvard, Daniel;Arpin, Monique
ERM(Ezrin，Radixin，Moesin)蛋白是膜-细胞骨架连接物，调节质膜特定结构域的结构和功能。到目前为止，所有已分析的后生动物都表达ERM蛋白。最近，对ERM蛋白功能的遗传分析在三种不同的生物中同时进行，它们是小鼠、黑腹果蝇和线虫。这些研究揭示了蛋白质功能在进化过程中的显著保守性。此外，他们还阐明了这些蛋白质在上皮细胞中发生的各种生理过程中所起的关键作用。(C)2006爱思唯尔B.V.保留所有权利。
ERM (Ezrin, Radixin, Moesin) proteins are membrane-cytoskeleton linkers that regulate the structure and the function of specific domains of the plasma membrane. ERM proteins are expressed in all metazoan analyzed so far. Genetic analysis of ERM protein functions has recently been performed simultaneously in three different organisms, mouse, Drosophila melanogaster and C. elegans. These studies have revealed a remarkable conservation of the protein functions through evolution. Moreover they have shed light on the crucial role these proteins play in various physiological processes that occur in epithelial cells. (c) 2006 Elsevier B.V All rights reserved.