INCIDENCE OF ULCERATIVE KERATITIS IN A DEFINED POPULATION FROM 1950 THROUGH 1988
INCIDENCE OF ULCERATIVE KERATITIS IN A DEFINED POPULATION FROM 1950 THROUGH 1988
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DOI：
10.1001/archopht.1993.01090120087027
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发表时间：
1993-12-01
影响因子：
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通讯作者：
BALLARD, D
中科院分区：
文献类型：
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作者：
ERIE, JC;NEVITT, MP;BALLARD, D
目的：确定溃疡性角膜炎的发病率，并评估导致溃疡性角膜炎的危险因素的趋势。设计：回顾性发病率队列研究。设置：一般社区。患者：1950年至1988年39年间，明尼苏达州奥姆斯特德县居民的基于人口的样本。主要观察指标：溃疡性角膜炎病例。结果：在奥姆斯特德县的131名居民（64名男性和67名女性）中诊断出141例溃疡性角膜炎。每10万人的平均年年龄调整发病率为5.3（95%置信区间为4.4至6.2）。从20世纪50年代（每10万人2.5例）到20世纪80年代（每10万人11.0例），奥姆斯特德县居民的溃疡性角膜炎发病率增加了435%（P=.001）。与接触透镜配戴相关的溃疡性角膜炎病例从20世纪50年代和60年代的0%增加到20世纪70年代的32%和20世纪80年代的52%。结论：该社区溃疡性角膜炎的发病率明显增加。在过去十年中，接触透镜配戴是溃疡性角膜炎发生的最重要危险因素。
Objective: To determine the incidence of ulcerative keratitis and to assess trends in risk factors leading to ulcerative keratitis. Design: Retrospective incidence cohort study. Setting: General community. Patients:Population-based sample of residents of Olmsted County, Minnesota, in the 39-year period between 1950 and 1988. Main Outcome Measure: Cases of ulcerative keratitis. Results: One hundred forty-one cases of ulcerative keratitis were diagnosed among 131 residents (64 men and 67 women) of Olmsted County. The mean annual age-adjusted incidence per 100 000 people was 5.3 (95% confidence interval, 4.4 to 6.2). A 435% increase in the incidence of ulcerative keratitis was observed in Olmsted County residents from the 1950s (2.5 per 100 000 people) to the 1980s (11.0 per 100 000 people) (P=.001). The cases of ulcerative keratitis associated with contact lens wear increased from 0% in the 1950s and 1960s to 32% in the 1970s and 52% in the 1980s. Conclusion: The incidence of ulcerative keratitis has increased significantly in this community. Contact lens wear was the most important risk factor for the development of ulcerative keratitis during the last decade.