Relating myocardial laminar architecture to shear strain and muscle fiber orientation
Relating myocardial laminar architecture to shear strain and muscle fiber orientation
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DOI：
10.1152/ajpheart.2001.280.5.h2222
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发表时间：
2001-05-01
影响因子：
4.8
通讯作者：
McCulloch, AD
中科院分区：
文献类型：
--
作者：
Arts, T;Costa, KD;McCulloch, AD
心肌纤维组织成约四个细胞厚的层状片。最近，有人提出，这些层与收缩期最大剪切平面一致。一般来说，有两个这样的平面，它们与主应变轴成+/-45度。这些平面不一定包含纤维轴。在本研究中，我们明确地增加了限制，片平面也应该包含肌纤维轴。在先前测量的三维透壁收缩期应变分布在六只狗的数学分析，我们计算了最大剪切平面，通过使用也测量肌纤维轴添加后者的约束。一般来说，对于这样的飞机两个解决方案被发现，这表明两个人口的片取向可能存在。沿左心室短轴或长轴平面沿着切割的预测片与透壁组织切片的角度与实验测量值惊人地相似。总之，片材与最大收缩剪切平面一致，但肌纤维轴包含在该平面内。片的方向不是一个独特的功能的透壁位置，但发生在两个不同的人群。
Cardiac myofibers are organized into laminar sheets about four cells thick. Recently, it has been suggested that these layers coincide with the plane of maximum shear during systole. In general, there are two such planes, which are oriented at +/-45 degrees to the main principal strain axes. These planes do not necessarily contain the fiber axis. In the present study, we explicitly added the constraint that the sheet planes should also contain the muscle fiber axis. In a mathematical analysis of previously measured three-dimensional transmural systolic strain distributions in six dogs, we computed the planes of maximum shear, adding the latter constraint by using the also-measured muscle fiber axis. Generally, for such planes two solutions were found, suggesting that two populations of sheet orientation may exist. The angles at which the predicted sheets intersected transmural tissue slices, cut along left ventricular short- or long-axis planes, were strikingly similar to experimentally measured values. In conclusion, sheets coincide with planes of maximum systolic shear subject to the constraint that the muscle fiber axis is contained in this plane. Sheet orientation is not a unique function of the transmural location but occurs in two distinct populations.