The changes in different symptom scores during subcutaneous immunotherapy in Chinese house dust mite allergic patients: a two-year, observational study
The changes in different symptom scores during subcutaneous immunotherapy in Chinese house dust mite allergic patients: a two-year, observational study
复制标题
中国屋尘螨过敏患者皮下免疫治疗期间不同症状评分的变化：一项为期两年的观察性研究。
DOI：
10.1017/s0022215119000094
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发表时间：
2019-03-01
影响因子：
1.7
通讯作者：
Zhi, L.
中科院分区：
文献类型：
--
作者：
Tu, Y.;Zhang, H.;Zhi, L.
背景皮下免疫疗法是治疗变应性鼻炎和变应性哮喘的有效和安全的方法。临床试验中采用不同的症状评分来评价皮下免疫治疗的疗效。共纳入58例对屋尘螨过敏的过敏性鼻炎患者，伴或不伴轻度哮喘。分别于治疗前、治疗后6、12、24个月进行症状评分、药物治疗评分、视觉模拟评分和生活质量评分。经过两年的皮下免疫治疗，哮喘症状评分几乎达到零，而鼻部症状评分仍然较高。在单致敏组和多致敏组之间，哮喘症状评分的变化存在显著差异（p < 0.05），并且比鼻部症状评分的变化更快。皮下免疫治疗后视觉模拟量表评分和药物治疗评分显著降低。用屋尘螨疫苗进行为期两年的皮下免疫治疗对单致敏和多致敏过敏患者都是有效的治疗方法。在中国屋尘螨过敏患者中，哮喘症状评分的变化明显不同，并且比鼻部症状评分的变化更快。
Background. Subcutaneous immunotherapy is an effective and safe treatment for allergic rhinitis and allergic asthma. Different symptom scores are used to evaluate the efficacy of subcutaneous immunotherapy in clinical trials.Method. A total of 58 allergic rhinitis patients sensitised to house dust mites, with or without mild asthma, were included. Symptom score, medication score, visual analogue scale score and quality of life were assessed before and after 6, 12 and 24 months of subcutaneous immunotherapy.Results. After two years of subcutaneous immunotherapy, asthma symptom scores nearly reached zero, whereas the scores remained higher for nasal symptoms. The changes in asthma symptom scores were markedly different ( p < 0.05) and occurred faster than the changes in nasal symptom scores when compared between monosensitised and polysensitised groups. Significant reductions in visual analogue scale score and medication score were demonstrated after subcutaneous immunotherapy.Conclusion. Two-year subcutaneous immunotherapy with house dust mite vaccine is an effective treatment for both monosensitised and polysensitised allergic patients. The changes in asthma symptom scores were markedly different and occurred quicker than the changes in nasal symptom scores in Chinese house dust mite allergic patients.