Polydopamine‐Mediated Surface Functionalization of Exosomes
Polydopamine‐Mediated Surface Functionalization of Exosomes
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DOI：
10.1002/cnma.202100078
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发表时间：
2021-03
期刊：
影响因子：
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通讯作者：
Chenyu Wang;K. Kimura;Jincai Li;Joseph J. Richardson;Mitsuru Naito;K. Miyata;T. Ichiki;H. Ejima
中科院分区：
文献类型：
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作者：
Chenyu Wang;K. Kimura;Jincai Li;Joseph J. Richardson;Mitsuru Naito;K. Miyata;T. Ichiki;H. Ejima
外泌体是细胞来源的细胞外囊泡，有望用于诊断和治疗。外泌体的表面特征决定了它们的生物命运，因此对于各种应用都很重要，然而表面修饰策略通常要么范围有限，要么需要复杂的设备或实验程序。在此，我们采用一种简单快速的方法通过聚多巴胺涂层来控制外泌体的表面性质。具体而言，聚多巴胺涂层允许通过次级反应进行可定制的功能化，这为外泌体的应用开辟了令人兴奋的途径。
Exosomes are cell‐derived extracellular vesicles that hold promise for diagnosis and therapy. The surface characteristics of exosomes dictate their biological fate and are therefore important for various applications, however surface modification strategies are generally either limited in scope or require complex equipment or experimental procedures. Herein, we employ a simple and fast method to control the surface properties of exosomes via polydopamine coating. Specifically, the polydopamine coating allowed for tailorable functionalization via secondary reactions, which opens exciting avenues for the application of exosomes.