HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS.
HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS.
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患有艾滋病相关综合症的人和有艾滋病风险的健康男同性恋者唾液中的 HTLV-III。
DOI：
10.1126/science.6093247
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Gallo,RC
中科院分区：
文献类型：
--
作者：
Groopman,JE;Salahuddin,SZ;Sarngadharan,MG;Markham,PD;Gonda,M;Sliski,A;Gallo,RC
20个人，包括4个获得性免疫缺陷综合征（AIDS），10个与艾滋病相关的复合体（ARC），和6个健康的同性恋男性在艾滋病的风险，外周血白细胞和唾液进行了比较，作为传染性人类T细胞白血病（嗜淋巴细胞）病毒III型（HTLV-III）的来源，该病毒被发现是艾滋病的病原体。所有的艾滋病和ARC患者和六个健康的同性恋者中的四个有证据表明以前暴露于HTLV-III的HTLV-III结构蛋白抗体的血清阳性。从一名艾滋病患者、四名ARC患者和两名健康同性恋男性的外周血中分离出感染性病毒，与以前的报告一致。HTLV-III也从四名ARC患者和四名健康同性恋者的唾液中分离出来。在一名艾滋病患者的唾液离心后制备的材料中，也通过电子显微镜观察到病毒。虽然艾滋病似乎不会通过偶然接触传播，但应考虑HTLV-III通过唾液传播的可能性。
Peripheral blood leukocytes and saliva from 20 individuals, including four with the acquired immune deficiency syndrome (AIDS), ten with AIDS-related complex (ARC), and six healthy homosexual males at risk for AIDS, were compared as sources of transmissible human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus found to be the etiologic agent of AIDS. All of the AIDS and ARC patients and four of the six healthy homosexuals had evidence of prior exposure to HTLV-III as indicated by seropositivity for antibody to HTLV-III structural proteins. Infectious virus was isolated from the peripheral blood of one of the AIDS patients, four of the ARC patients, and two of the healthy homosexual males, consistent with previous reports. HTLV-III was also isolated from the saliva of four of the ARC patients and four of the healthy homosexuals. Virus was also observed by electron microscopy in material prepared by centrifugation of the saliva of one AIDS patient. Although AIDS does not appear to be transmitted by casual contact, the possibility that HTLV-III can be transmitted by saliva should be considered.