REGULATION OF ACID PROTEASES DURING GROWTH, QUIESCENCE AND STARVATION IN NORMAL AND TRANSFORMED-CELLS
REGULATION OF ACID PROTEASES DURING GROWTH, QUIESCENCE AND STARVATION IN NORMAL AND TRANSFORMED-CELLS
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DOI：
10.1038/267252a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
SHIER, WT
中科院分区：
文献类型：
--
作者：
LOCKWOOD, TD;SHIER, WT
细胞蛋白质以连续但可变的周转状态存在，总蛋白质含量是合成和降解相对速率的净结果。细胞生长是蛋白质的净积累，尽管每个过程的相对贡献仍然不确定，但细胞生长的停止可能是合成减少1和/或降解增加2的结果。我们在这里报告说，停止生长和饥饿在正常细胞中是伴随着酸性蛋白酶活性的大幅增加，然而，转化细胞未能停止生长也未能提高酶负责水解的绝大多数的肽键。
CELL protein exists in a continual but variable state of turnover and the total protein content is the net result of the relative rates of synthesis and degradation. Cell growth is the net accumulation of protein, and although the relative contribution of each process is still uncertain the cessation of cell growth could be the result of a decrease in synthesis1and/or an increase in degradation2. We report here that cessation of growth and starvation in normal cells is accompanied by a large increase in acid protease activity; however, transformed cells which fail to stop growing also fail to elevate the enzymes responsible for hydrolysis of the great majority of peptide bonds.