Low-grade systemic inflammation in overweight children
Low-grade systemic inflammation in overweight children
复制标题
DOI：
10.1542/peds.107.1.e13
复制
发表时间：
2001-01-01
期刊：
影响因子：
8
通讯作者：
Harris, TB
中科院分区：
文献类型：
--
作者：
Visser, M;Bouter, LM;Harris, TB
Objective.人类脂肪组织表达并释放促炎细胞因子白细胞介素-6，可能在体脂肪过多的人中诱导低度全身性炎症。为了限制炎症相关疾病和亚临床心血管疾病的潜在混淆，我们检验了超重与儿童低度全身性炎症相关的假设。第三次全国健康与营养调查，1988-1994年，美国人口的代表性样本。共有3512名8至16岁的儿童。血清C-反应蛋白浓度（CRP; > 0.22 mg/dL）和白色血细胞计数（10（9）个细胞/L）升高。CRP升高存在于7.1%的男孩和6.1%的女孩。超重儿童（定义为体重指数或3个皮褶（三头肌、肩胛下和髂上）之和高于性别特异性第85百分位数）比体重正常的儿童更有可能CRP升高。在调整潜在混杂因素（包括吸烟和健康状况）后，基于体重指数，超重男孩的比值比（OR）为3.74（95%置信区间[CI]：1.66-8.43），超重女孩的OR为3.17（95% CI：1.60-6.28）。基于3个皮褶的总和，男孩和女孩的OR分别为5.11（95% CI：2.36-11.06）和2.89（95% CI：1.49-5.59）。超重还与统计学显著性较高的白色血细胞计数相关。当仅限于健康、不吸烟、不使用雌激素的儿童时，结果相似。在8至16岁的儿童中，超重与较高的CRP浓度和较高的白色血细胞计数相关。这些发现表明超重儿童存在低度全身性炎症。
Objective. Human adipose tissue expresses and releases the proinflammatory cytokine interleukin-6, potentially inducing low-grade systemic inflammation in persons with excess body fat. To limit potential confounding by inflammation-related diseases and subclinical cardiovascular disease, we tested the hypothesis that overweight is associated with low-grade systemic inflammation in children.Design and Setting. The third National Health and Nutrition Examination Survey, 1988-1994, a representative sample of the US population.Participants. A total of 3512 children 8 to 16 years of age.Outcome Measures. Elevated serum C-reactive protein concentration (CRP; >.22 mg/dL) and white blood cell count (10(9) cells/L).Results. Elevated CRP was present in 7.1% of the boys and 6.1% of the girls. Overweight children (defined as having a body mass index or a sum of 3 skinfolds (triceps, subscapula, and supra-iliac) above the gender-specific 85th percentile) were more likely to have elevated CRP than were their normal-weight counterparts. After adjustment for potential confounders, including smoking and health status, the odds ratio (OR) was 3.74 (95% confidence interval [CI]: 1.66-8.43) for overweight boys and the OR was 3.17 (95% CI: 1.60-6.28) for overweight girls, based on the body mass index. Based on the sum of 3 skinfolds, these ORs were 5.11 (95% CI: 2.36-11.06) and 2.89 (95% CI: 1.49-5.59) for boys and girls, respectively. Overweight was also associated with statistically significant higher white blood cell counts. The results were similar when restricted to healthy, non-smoking, nonestrogen-using children.Conclusions. In children 8 to 16 years of age, overweight is associated with higher CRP concentrations and higher white blood cell counts. These findings suggest a state of low-grade systemic inflammation in overweight children.