Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.
Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.
复制标题
DOI：
10.1016/j.trci.2017.08.004
复制
发表时间：
2017-11-01
期刊：
影响因子：
--
通讯作者：
Salmon, Eric
中科院分区：
文献类型：
--
作者：
Bahri, Mohamed Ali;Plenevaux, Alain;Salmon, Eric
简介：采用氟-18 UCB-H （[18F]UCB-H）和正电子发射断层扫描（PET）检测突触囊泡蛋白2A的脑分布。方法：获取健康志愿者（2名年轻参与者和2名老年人）的突触密度图像。输入功能通过动脉采血测量（动脉输入功能），并通过颈动脉活动的PET图像得出（图像衍生输入功能）。Logan图形分析估计区域突触囊泡蛋白2A的分布体积。结果：[18F]UCB-H摄取在皮层和皮层下灰质中普遍存在。动脉输入函数和图像衍生输入函数提供了高度线性关系的区域分布体积。讨论：[18F]UCB-H的大脑分布与最近观察到的碳-11 UCB-J相似（[11C]UCB-J）。当没有合适的参考区域时，可以使用动态PET颈动脉活动，在没有侵入性动脉采血的情况下进行准确的[18F]UCB-H定量。正常和病理性衰老的脑突触密度可在体内进行研究。
INTRODUCTION: Brain distribution of synaptic vesicle protein 2A was measured with fluorine-18 UCB-H ([18F]UCB-H) and positron emission tomography (PET).METHODS: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume.RESULTS: [18F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship.DISCUSSION: The cerebral distribution of [18F]UCB-H is similar to that recently observed with carbon-11 UCB-J ([11C]UCB-J). An accurate [18F]UCB-H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied invivo in normal and pathological aging.