New Insights in the Interplay Between African Swine Fever Virus and Innate Immunity and Its Impact on Viral Pathogenicity.
New Insights in the Interplay Between African Swine Fever Virus and Innate Immunity and Its Impact on Viral Pathogenicity.
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DOI：
10.3389/fmicb.2022.958307
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
非洲猪瘟病毒(ASFV)在欧洲和亚洲的持续传播是对牲畜健康的重大威胁，造成数十亿美元的收入损失和全球养猪业的重大扰动。非洲猪瘟(ASF)的一个显著特征是存在不同形式的疾病，从急性到慢性，死亡率接近100%，临床表现轻微。这些致病性上的差异与ASFV减毒株(而强毒株不存在)的基因组变化以及感染动物免疫反应的差异有关。在这篇简短的综述中，我们总结了目前关于ASFV致病性与感染宿主诱导的先天性免疫反应之间的联系的知识，尤其是ASFV检测所涉及的途径。事实上，最近的研究已经强调了DNA传感器cGAS在ASFV传感中的关键作用。我们讨论了可能参与ASFV感知和炎症体激活的其他途径，并总结了有关病毒ASFV基因参与干扰素和核因子-kappaB(NF-κB)途径调控的最新研究结果。
The continuous spread of African swine fever virus (ASFV) in Europe and Asia represents a major threat to livestock health, with billions of dollars of income losses and major perturbations of the global pig industry. One striking feature of African swine fever (ASF) is the existence of different forms of the disease, ranging from acute with mortality rates approaching 100% to chronic, with mild clinical manifestations. These differences in pathogenicity have been linked to genomic alterations present in attenuated ASFV strains (and absent in virulent ones) and differences in the immune response of infected animals. In this mini-review, we summarized current knowledge on the connection between ASFV pathogenicity and the innate immune response induced in infected hosts, with a particular focus on the pathways involved in ASFV detection. Indeed, recent studies have highlighted the key role of the DNA sensor cGAS in ASFV sensing. We discussed what other pathways may be involved in ASFV sensing and inflammasome activation and summarized recent findings on the viral ASFV genes involved in the modulation of the interferon (IFN) and nuclear factor kappa B (NF-κB) pathways.
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影响因子：
6.7
作者：
Cuesta-Geijo MÁ;García-Dorival I;Del Puerto A;Urquiza J;Galindo I;Barrado-Gil L;Lasala F;Cayuela A;Sorzano COS;Gil C;Delgado R;Alonso C
通讯作者：
Alonso C
影响因子：
5
作者：
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影响因子：
2.2
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通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
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影响因子：
3.5
作者：
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