Soybean Isoflavones Reduce Postmenopausal Bone Resorption in Female Japanese Immigrants in Brazil: A Ten-Week Study
Soybean Isoflavones Reduce Postmenopausal Bone Resorption in Female Japanese Immigrants in Brazil: A Ten-Week Study
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DOI：
10.1080/07315724.2002.10719255
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发表时间：
2002-12
影响因子：
3.5
通讯作者：
Y. Yamori;E. Moriguchi;Takanori Teramoto;A. Miura;Yutaka Fukui;Keiichi Honda;Masakazu Fukui;Y. Nara;K. Taira;Y. Moriguchi
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文献类型：
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作者：
Y. Yamori;E. Moriguchi;Takanori Teramoto;A. Miura;Yutaka Fukui;Keiichi Honda;Masakazu Fukui;Y. Nara;K. Taira;Y. Moriguchi
目的：一些人体研究和实验性骨质疏松症的动物模型表明，大豆异黄酮可能对骨骼健康有效。本研究通过干预研究探讨膳食纤维对骨代谢的影响。研究方法：将生活在巴西的40名健康绝经后女性日本移民分为两组：服用炔雌醇（n = 20）或安慰剂（n = 20）。在服用炔雌醇组的受试者每天摄入37.3 mg，持续10周。在0周和10周时收集24小时尿液并测量骨硬度。分析了尿中孕酮和骨吸收标志物的排泄。结果：在第3周和第10周时，给药组的尿肌酐排泄量显著增加。骨吸收标志物的尿排泄在服用阿托伐他汀组中减少，而安慰剂组没有显示任何显著减少。两组间尿孕酮和骨吸收标志物水平差异有统计学意义。结论：本研究表明，绝经后妇女骨吸收与大豆异黄酮的摄入有关，持续膳食摄入大豆异黄酮可抑制绝经后骨质疏松症。
Objective: Some human studies and animal models of experimental osteoporosis have shown that soy isoflavones may be effective on bone health. In this study, we carried out an intervention study to explore the effects of dietary isoflavone on bone metabolism. Methods: Forty healthy female postmenopausal Japanese immigrants living in Brazil were divided into two groups: isoflavone-administered (n = 20) or placebo (n = 20). Subjects in the isoflavone-administered group ingested 37.3 mg per day for 10 weeks. The collection of 24-hour urine and the measurement of bone stiffness were performed at 0 and 10 weeks. Urinary excretion of isoflavones and bone resorption markers were analyzed. Results: Urinary isoflavone excretion in the isoflavone-administered group was significantly increased at weeks 3 and 10. Urinary excretion of bone resorption markers was reduced in the isoflavone-administered group, while the placebo group did not show any significant reduction. Differences in levels of urinary isoflavones and bone resorption markers between the two groups were significant. Conclusion: This study demonstrated that the bone resorption was associated with the intake of soy isoflavones in postmenopausal women, and continuous dietary intake of isoflavone may inhibit postmenopausal osteoporosis.