Transplantation of an indigenous neural stem cell population leading to hyperplasia and atypical integration.
Transplantation of an indigenous neural stem cell population leading to hyperplasia and atypical integration.
复制标题
移植本土神经干细胞群导致增生和非典型整合。
DOI：
10.1089/153623002753631995
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Laywell,EricD
中科院分区：
文献类型：
--
作者：
Zheng,Tong;Steindler,DennisA;Laywell,EricD
星形胶质细胞在体外产生多能克隆细胞时表现出神经干细胞的特征。为了观察体内是否存在正常的线索，可以指导这些星形胶质细胞产生神经元谱系的细胞，我们将这些星形胶质细胞移植到持续神经发生的小鼠室管膜下区/吻侧迁移流中。移植的星形胶质细胞具有迁移特征，加入本地神经母细胞链，并迁移到嗅球中。此外，一些移植的星形胶质细胞“归巢”到侧脑室，在那里它们变得增生，形成由混合表型细胞组成的球形结构，附着在脑室壁上，最终穿透并分散在周围的脑实质内。我们提出，在神经系统疾病中使用干细胞移植的兴趣，增生和多能星形细胞干细胞本地群体明显非典型整合的发现表明，在开始自体神经干细胞移植之前需要谨慎。
Astrocytes exhibit neural stem cell characteristicsin vitroby generating multipotent clones of cells. In order to see if normal cues are presentin vivothat can direct these astrocytes to generate cells of neuronal lineage, the astrocytes were transplanted into the persistently neurogenic mouse subependymal zone/rostral migratory stream. Grafted astrocytes assumed migratory profiles, joined chains of indigenous neuroblasts, and migrated into the olfactory bulb. Additionally, however, some grafted astrocytes "homed" to the lateral ventricle where they became hyperplastic, forming spherical structures composed of cells of mixed phenotype that attached to the ventricular wall, and eventually penetrated and dispersed within surrounding brain parenchyma. It is proposed that, with an interest in the use of stem cell transplants for neurological disease, findings of hyperplasia and apparent atypical integration of a native population of multipotent astrocytic stem cells suggest the need for caution before beginning even autologous neural stem cell transplants.