The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study.
The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study.
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DOI：
10.1186/1471-2350-10-18
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发表时间：
2009-02-27
影响因子：
--
通讯作者：
Vogel U
中科院分区：
文献类型：
--
作者：
Andersen V;Agerstjerne L;Jensen D;Østergaard M;Saebø M;Hamfjord J;Kure E;Vogel U
吸烟，饮食因素和饮酒是已知的生活方式因素，有助于胃肠道癌的发生。致癌物处理中的遗传变异可能会影响癌症风险。多药耐药1（MDR 1/ABCB 1）基因编码转运蛋白P-糖蛋白（一种III期异生物质转运蛋白）。P-糖蛋白存在于肠粘膜内层，并限制这些多环芳烃中某些致癌物质的吸收。此外，P-糖蛋白转运各种内源性底物，如参与炎症的细胞因子和趋化因子，并可能因此影响妊娠的风险。因此，改变P-糖蛋白功能的遗传变异可能与结直肠癌（CRC）的风险相关。我们先前在丹麦的一项研究中发现MDR 1内含子3 G-rs3789243-A多态性与CRC风险之间存在关联。本研究的目的是调查挪威人群中MDR 1多态性是否与结直肠腺瘤（CA）和CRC的风险相关。采用病例对照设计，在167例癌症、990例腺瘤和400例对照中评估了挪威人群MDR 1内含子3 G-rs3789243-A多态性与结直肠癌和腺瘤风险之间的关联。通过等位基因鉴别确定基因型。采用二项Logistic回归分析估计OR值和95%CI。MDR 1基因多态性（G-rs3789243-A）与结直肠腺瘤或结直肠癌之间没有关联。与纯合子野生型携带者相比，MDR 1内含子3变异等位基因携带者发生腺瘤和结直肠癌的优势比（95%CI）分别为0.97（0.72-1.29）和0.70（0.41-1.21）。MDR 1内含子3（G-rs3789243-A）多态性与结直肠腺瘤或癌的风险无关。因此，这种MDR 1多态性似乎并没有发挥重要的作用，在结直肠癌的发生在这一人群。
Smoking, dietary factors, and alcohol consumption are known life style factors contributing to gastrointestinal carcinogenesis. Genetic variations in carcinogen handling may affect cancer risk. The multidrug resistance 1(MDR1/ABCB1) gene encodes the transport protein P-glycoprotein (a phase III xenobiotic transporter). P-glycoprotein is present in the intestinal mucosal lining and restricts absorption of certain carcinogens, among these polycyclic aromatic hydrocarbons. Moreover, P-glycoprotein transports various endogenous substrates such as cytokines and chemokines involved in inflammation, and may thereby affect the risk of malignity. Hence, genetic variations that modify the function of P-glycoprotein may be associated with the risk of colorectal cancer (CRC). We have previously found an association between the MDR1 intron 3 G-rs3789243-A polymorphism and the risk of CRC in a Danish study population. The aim of this study was to investigate if this MDR1 polymorphism was associated with risk of colorectal adenoma (CA) and CRC in the Norwegian population. Using a case-control design, the association between the MDR1 intron 3 G-rs3789243-A polymorphism and the risk of colorectal carcinomas and adenomas in the Norwegian population was assessed in 167 carcinomas, 990 adenomas, and 400 controls. Genotypes were determined by allelic discrimination. Odds ratio (OR) and 95 confidence interval (95% CI) were estimated by binary logistic regression. No association was found between the MDR1 polymorphism (G-rs3789243-A) and colorectal adenomas or cancer. Carriers of the variant allele of MDR1 intron 3 had odds ratios (95% CI) of 0.97 (0.72–1.29) for developing adenomas, and 0.70 (0.41–1.21) for colorectal cancer, respectively, compared to homozygous wild type carriers. The MDR1 intron 3 (G-rs3789243-A) polymorphism was not associated with a risk of colorectal adenomas or carcinomas in the present Norwegian study group. Thus, this MDR1 polymorphism does not seem to play an important role in colorectal carcinogenesis in this population.
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影响因子：
5.8
作者：
Morita, N;Yasumori, T;Nakayama, K
通讯作者：
Nakayama, K
影响因子：
3.5
作者：
Ho, GT;Soranzo, N;Satsangi, J
通讯作者：
Satsangi, J
影响因子：
2
作者：
Moriya, Y;Nakamura, T;Okumura, K
通讯作者：
Okumura, K
DOI：
10.1089/154099903321576574
发表时间：
2003-03-01
期刊：
JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
影响因子：
--
作者：
Giovannucci, E
通讯作者：
Giovannucci, E
影响因子：
3.9
作者：
Hilgendorf, Constanze;Ahlin, Gustav;Karlsson, Johan
通讯作者：
Karlsson, Johan