Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
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DOI：
10.1016/j.cardfail.2008.07.178
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发表时间：
2008-09
影响因子：
6
通讯作者：
K. Hayashida;M. Sano;I. Ohsawa;K. Shinmura;K. Tamaki;Kensuke Kimura;J. Endo;S. Ohta;K. Fukuda-K.-F
中科院分区：
文献类型：
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作者：
K. Hayashida;M. Sano;I. Ohsawa;K. Shinmura;K. Tamaki;Kensuke Kimura;J. Endo;S. Ohta;K. Fukuda-K.-F
吸入氢气 (H2) 已被证明可以通过减少啮齿动物的缺血再灌注损伤来限制大脑和肝脏的梗塞体积。当转化为临床实践时，这种疗法必须最常应用于急性心肌梗塞患者的治疗，因为梗塞相关的闭塞冠状动脉的血管成形再通术是常规进行的。因此，我们研究氢气是否具有针对大鼠缺血再灌注损伤的心脏保护作用。在离体灌注心脏中，氢气可增强缺氧复氧后左心室功能的恢复。吸入的氢气可以快速输送，在闭塞的梗塞相关动脉的冠状动脉血流重新建立之前可以到达“处于危险中”的缺血心肌。在缺血和再灌注期间吸入不可燃水平的氢气可减少梗塞面积而不改变血流动力学参数，从而防止有害的左心室重构。因此，吸入氢气是减轻冠状动脉再通时缺血再灌注损伤的有前途的策略。
Inhalation of hydrogen (H2) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia–reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H2gas confers cardioprotection against ischemia–reperfusion injury in rats. In isolated perfused hearts, H2gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H2gas is rapidly transported and can reach ‘at risk’ ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H2gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H2gas is promising strategy to alleviate ischemia–reperfusion injury coincident with recanalization of coronary artery.