Balancing the Anti‐Bacterial and Pro‐Osteogenic Properties of Ti‐Based Implants by Partial Conversion of ZnO Nanorods into Hybrid Zinc Phosphate Nanostructures
Balancing the Anti‐Bacterial and Pro‐Osteogenic Properties of Ti‐Based Implants by Partial Conversion of ZnO Nanorods into Hybrid Zinc Phosphate Nanostructures
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DOI：
10.1002/adfm.202311812
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发表时间：
2024-01
影响因子：
19
通讯作者：
Feilong Zhao;Ang Gao;Qing Liao;Yanyue Li;Ihsan Ullah;Ya Zhao;Xiaoxue Ren;L. Tong;Xin Li-X
中科院分区：
文献类型：
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作者：
Feilong Zhao;Ang Gao;Qing Liao;Yanyue Li;Ihsan Ullah;Ya Zhao;Xiaoxue Ren;L. Tong;Xin Li-X
细菌感染和下部骨结合是钛基种植体相关的主要并发症。尽管表面工程氧化锌纳米棒具有显著的抗菌能力，但其显著的细胞毒性阻碍了其潜在的生物医学应用。受氧化锌在体内降解过程的启发，在磷酸氢溶液中，通过简单的水热处理，将氧化锌纳米棒转化为热力学上更稳定的磷酸锌(Zn3(PO4)2)。通过调节转化率，可以对纳米棒的表面形貌、锌离子(Zn2+)的释放和活性氧物种的生成进行精细的调控，从而在保持其抗菌性能的同时克服纳米棒的细胞毒性。此外，通过重新编程人骨髓间充质干细胞的代谢构型，从ZnO/Zn3(PO4)2杂化涂层中释放出适量的锌离子可促进人骨髓间充质干细胞的成骨分化和细胞外基质矿化。兔股骨种植体相关感染模型表明，在病原菌存在的情况下，复合氧化锌/磷酸锌涂层甚至可以促进骨整合。这种表面改性策略使钛基种植体具有优异的抗菌和促成骨性能，在骨科和牙科应用中具有巨大的临床潜力。
Bacterial infection and inferior osseointegration are major complications associated with titanium (Ti) based implants. Although surface‐engineered zinc oxide (ZnO) nanorods exhibit remarkable antibacterial ability, their potential biomedical applications are hampered by their pronounced cytotoxicity. Herein, inspired by the in vivo degradation process of znic, ZnO nanorods are converted into thermodynamically more stable zinc phosphate (Zn3(PO4)2 ）through a simple hydrothermal treatment in a hydrogen phosphate solution. By adjusting the conversion ratio, the surface morphology, release of zinc ions (Zn2+), and generation of reactive oxygen species can be finely tailored to overcome the cytotoxicity of ZnO nanorods while preserving their antibacterial capability. Furthermore, an optimized amount of Zn2+ released from the ZnO/Zn3(PO4)2 hybrid coating enhances osteogenic differentiation and extracellular matrix mineralization of human bone marrow mesenchymal stem cells by reprogramming their metabolic configuration. An implant‐related infection model in rabbit femurs indicates that the hybrid ZnO/Zn3(PO4)2 coating can even promote osseointegration in the presence of pathogenic bacteria. This surface modification strategy which endows Ti‐based implants with superior anti‐bacterial and pro‐osteogenic properties holds great clinical potential for orthopedic and dental applications.