Genetic and environmental influences on the relative timing of pubertal change
Genetic and environmental influences on the relative timing of pubertal change
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DOI：
10.1375/1369052042335278
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发表时间：
2004-10-01
期刊：
影响因子：
--
通讯作者：
Worthman, C
中科院分区：
文献类型：
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作者：
Eaves, L;Silberg, J;Worthman, C
一个多类别项目反应理论模型的特点发展变化的三个项目有关的青春期双胞胎女孩和男孩的评估。该模型允许的固定效应的年龄赞同的反应和随机效应的个体差异的青春期变化的时间相对于实际年龄的概率。在女孩中，该模型应用了来自弗吉尼亚州青少年行为发展双胞胎研究的双胞胎对（N = 414名女性单卵[MZ]和197名女性双卵[DZ]对）和来自男孩-女孩对（N = 300名双胞胎）的女性双胞胎的三波数据。在男孩中，数据包括318个MZ和185个DZ对以及297个来自男孩女孩对的男性双胞胎。在8-17岁的女孩和男孩中，分别有3172和2790个单独的双胞胎评估。双胞胎数据的可用性允许基因的贡献，共享的环境和个人独特的环境经验，以解决青春期变化的相对时间。混合模型的参数，包括年龄的固定效应和基因和环境的随机效应估计马尔可夫链蒙特卡罗模拟使用吉布斯抽样的BUGS算法。青春期时间相对于年龄的随机差异的估计标准差为女孩0.96岁，男孩1.01岁。估计的青春期变化相对时间的组内相关性在MZ女孩中为0.99+/-0.01，在DZ女孩中为0.52+/-0.02，在MZ男孩中为0.88+/-0.04，在DZ男孩中为0.44+/-0.02，表明遗传因素对两性青春期变化的相对时间有很大的贡献。加性遗传因素估计占女孩随机效应总方差的96.3+/-3.3%，88.0+/-3.6%。共同的环境影响在女孩中占3.6+/-3.4%，在男孩中占0%。在女孩中，非共享环境效应解释了总剩余方差的0.1+/-0.1%。男孩的可比数字为12.0+/-3.6%。
A multicategory item-response theory model was developed to characterize developmental changes in three items relating to the assessment of puberty in adolescent twin girls and boys. The model allowed for the fixed effects of age on probability of endorsing the responses and for the random effects of individual differences on the timing of pubertal changes relative to chronological age. In girls, the model was applied three-wave data on twin pairs (N = 414 female monozygotic [MZ] and 197 female dizygotic [DZ] pairs) and female twins from boy-girl pairs (N = 300 twins) from the Virginia Twin Study of Adolescent Behavioral Development. In boys, the data comprised 318 MZ and 185 DZ pairs and 297 male twins from boy-girl pairs. A total of 3172 and 2790 individual twin assessments were available in girls and boys, respectively, spanning ages 8-17 years. The availability of twin data allows the contributions of genes, the shared environment and individual unique environmental experiences to be resolved in the relative timing of pubertal changes. Parameters of the mixed model including fixed effects of age and random effects of genes and environment were estimated by Markov Chain Monte Carlo simulations using the BUGS algorithm for Gibbs sampling. The estimated standard deviation of random differences in the timing of puberty relative to age was 0.96 years in girls and 1.01 years in boys. The estimated intraclass correlations for the relative timing of pubertal changes were 0.99+/-0.01 in MZ girls, 0.52+/-0.02 in DZ girls, 0.88+/-0.04 in MZ boys and 0.44+/-0.02 in DZ boys, indicating a very large contribution of genetic factors to the relative timing of pubertal change in both sexes. Additive genetic factors account for an estimated 96.3+/-3.3% of the total variance in random effects in girls and 88.0+/-3.6% in boys. Shared environmental influences account for 3.6+/-3.4% in girls and 0% in boys. In girls, nonshared environmental effects explain 0.1+/-0.1% of the total residual variance. The comparable figure in boys is 12.0+/-3.6%.