Insolubilized properties of UV-irradiated CO3 apatite-collagen composites.
Insolubilized properties of UV-irradiated CO3 apatite-collagen composites.
复制标题
紫外线照射的 CO3 磷灰石-胶原蛋白复合材料的不溶特性。
DOI：
10.1016/0142-9612(90)90080-a
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发表时间：
1990
期刊：
影响因子：
14
通讯作者：
M. Sakuda
中科院分区：
文献类型：
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作者：
M. Okazaki;H. Ohmae;J. Takahashi;H. Kimura;M. Sakuda
为了检查对生物硬组织的反应，在pH 7.4和60°C下合成了化学组成和结晶度与骨相似的含碳酸盐的羟基磷灰石。将磷灰石粉末与胶原溶液混合，胶原溶液的抗原性已经通过酶处理去除，并形成磷灰石-胶原颗粒。在0.9%NaCl溶液中孵育1周后，在3.6 MPa的应力下，通过UV照射4 h的不溶解后，复合材料表现出显着减少的崩解和保持其形状。植入大鼠颅骨骨膜下，显示出良好的生物相容性。紫外线照射的样品保持其功能良好，并与新创建的材料植入后3周包装。
To examine the response to biological hard tissues, a carbonate-containing hydroxyapatite with chemical composition and crystallinity similar to those of bone was synthesized at pH 7.4 and 60°C. The apatite powder was mixed with collagen solution, whose antigenicity had been removed by enzymatic treatment, and formed into apatite-collagen pellets. After insolubilization by UV-irradiation for 4 h, the composites showed remarkably reduced disintegration and maintained their shape under 3.6 MPa of stress after 1 wk incubation in 0.9% NaCI solution. They showed good biocompatibilty when implanted beneath the periosteum cranii of rats. The UV-irradiated sample kept its features well and was packed with newly created material 3 wk after implantation.
M.Okazaki：“通过紫外线照射使磷灰石-胶原蛋白复合物不溶解”生物材料。
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