In vitro anticancer activity of twelve Chinese medicinal herbs
In vitro anticancer activity of twelve Chinese medicinal herbs
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DOI：
10.1002/ptr.1702
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发表时间：
2005-07-01
影响因子：
7.2
通讯作者：
Campbell, MJ
中科院分区：
文献类型：
--
作者：
Shoemaker, M;Hamilton, B;Campbell, MJ
研究了知母、艾蒿、没药、苦参、皂角、女贞子、掌叶大黄、茜草、丹参、半枝莲、钩藤、五味子等12种中草药的水提物对8种癌细胞和正常人乳腺上皮细胞增殖的抑制作用。使用了代表不同组织(乳腺、肺、胰腺和前列腺)的5个人癌细胞系和3个小鼠癌细胞系。所有的粗水提物对部分或全部癌细胞都显示出生长抑制活性，但只有两种对正常乳腺上皮细胞显示出活性。总体而言，与人类细胞系相比，小鼠细胞系对大多数提取物倾向于更敏感。在人类细胞系中，观察到两种提取物的细胞类型特异性。这些结果表明中草药作为抗肿瘤药物的潜在用途，并建议进一步研究其作用机制(S)和分离活性抗肿瘤化合物。版权所有(C)2005 John Wiley&Sons，Ltd.
Aqueous extracts of 12 Chinese medicinal herbs, Anemarrhena asphodeloides, Artemisia argyi, Commiphora myrrha, Duchesnea indica, Gleditsia sinensis, Ligustrum lucidum, Rheum palmatum, Rubia cordifolia, Salvia chinensis, Scutellaria barbata, Uncaria rhychophylla and Vaccaria segetalis were evaluated for their antiproliferative activity on eight cancer cell lines as well as on normal human mammary epithelial cells. Five human and three murine cancer cell lines representing different tissues (breast, lung, pancreas and prostate) were used. All the crude aqueous extracts demonstrated growth inhibitory activity on some or all of the cancer cell lines, but only two showed activity against the normal mammary epithelial cells. Overall, the murine cell lines tended to be more sensitive to most of the extracts compared with the human cell lines. Among the human cell lines, cell type specificity was observed for two extracts. These results indicate the potential use of traditional Chinese medicinal herbs as antineoplastic agents and suggest that further studies evaluating their mechanism(s) of action and the isolation of active antitumor compounds are warranted. Copyright (c) 2005 John Wiley & Sons, Ltd.