Straighten up and fly right-microtubule dynamics and organization of non-centrosomal arrays in higher plants
Straighten up and fly right-microtubule dynamics and organization of non-centrosomal arrays in higher plants
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DOI：
10.1016/j.ceb.2007.12.004
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发表时间：
2008-02-01
影响因子：
7.5
通讯作者：
Ehrhardt, David W.
中科院分区：
文献类型：
--
作者：
Ehrhardt, David W.
活细胞成像和遗传学研究表明，植物细胞中的皮层微管阵列是动态结构，其中微管（MT）束在创建阵列组织和功能中发挥关键作用。创建和组织这些阵列的重要步骤包括招募成核复合物到细胞皮层和先前建立的MT的晶格，新创建的MT与细胞皮层的关联，从成核位点释放MT，通过聚合物微研磨运输释放的MT，以及微研磨MT之间的后续相互作用。MT相互作用的结果包括诱导的灾难，切断，以及通过捆绑相互作用捕获和重定向生长的聚合物末端。总之，这些属性预测的能力，自我排序，可能会发挥重要作用，在建立并行组织的阵列。
Live cell imaging and genetic studies are demonstrating that cortical microtubule arrays in plant cells are dynamic structures in which microtubule (MT) bundles play a key role in creating array organization and function. Steps important for creating and organizing these arrays include recruitment of nucleation complexes to the cell cortex and to the lattices of previously established MTs, association of newly created MTs to the cell cortex, release of MTs from sites of nucleation, transport of released MTs by polymer treadmilling, and subsequent interactions between treadmilling MTs. The results of MT interactions include induced catastrophe, severing, and the capture and reorientation of growing polymer ends by bundling interactions. Together, these properties predict a capacity for self-ordering that is likely to play an important role in establishing the parallel organization of the arrays.