β-hydroxy-β-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors
β-hydroxy-β-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors
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DOI：
10.1093/jn/130.8.1937
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发表时间：
2000-08-01
影响因子：
4.2
通讯作者：
Fuller, JC
中科院分区：
文献类型：
--
作者：
Nissen, S;Sharp, RL;Fuller, JC
亮氨酸代谢物 β-羟基-β-甲基丁酸 (HMB) 可以增强运动对肌肉大小和力量的影响。尽管一些动物和人类报告表明 HMB 是安全的，但人类的定量安全数据尚未得到明确报告。这项工作的目的是总结九项研究中收集的安全数据，其中人类每天喂食 3 g HMB。这些研究持续 3 至 8 周，包括男性和女性、年轻人和老年人、锻炼或不锻炼的人。通过血液化学和血液学评估器官和组织功能；通过情绪概况测试 (Circumplex) 测量对情绪感知的微妙影响，并通过 32 个与健康相关的问题评估 HMB 的耐受性。 HMB 不会对组织健康和功能的任何替代标志物产生不利影响。 Circumplex 情绪概况表明，HMB 显着降低（改善）了消极情绪的一项指标（未激活的不愉快情绪类别，P < 0.05）。没有显示 HMB 的不良影响。与安慰剂相比，补充 HMB 导致总胆固醇净下降（5.8%，P < 0.03）、LDL 胆固醇下降（7.3%，P < 0.01）和收缩压下降（4.4 mm Hg，P < 0.05）。 HMB 对心血管健康替代指标的这些影响可能会降低心脏病发作和中风的风险。总之，九项实验收集的客观数据表明，HMB 可以安全地作为运动的强效辅助剂，并且健康的客观衡量标准和幸福感普遍得到增强。
The leucine metabolite, beta-hydroxy-beta-methylbutyrate (HMB) enhances the effects of exercise on muscle size and strength. Although several reports in animals and humans indicate that HMB is safe, quantitative safety data in humans have not been reported definitively. The objective of this work was to summarize safety data collected in nine studies in which humans were fed 3 g HMB/d. The studies were from 3 to 8 wk in duration, included both males and females, young and old, exercising or nonexercising. Organ and tissue function was assessed by blood chemistry and hematology; subtle effects on emotional perception were measured with an emotional profile test (Circumplex), and tolerance of HMB was assessed with a battery of 32 health-related questions. HMB did not adversely affect any surrogate marker of tissue health and function. The Circumplex emotion profile indicated that HMB significantly decreased (improved) one indicator of negative mood (Unactivated Unpleasant Affect category, P < 0.05). No untoward effects of HMB were indicated. Compared with the placebo, HMB supplementation resulted in a net decrease in total cholesterol (5.8%, P < 0.03), a decrease in LDL cholesterol (7.3%, P < 0.01) and a decrease in systolic blood pressure (4.4 mm Hg, P < 0.05). These effects of HMB on surrogate markers of cardiovascular health could result in a decrease in the risk of heart attack and stroke. In conclusion, the objective data collected across nine experiments indicate that HMB can be taken safely as an ergogenic aid for exercise and that objective measures of health and perception of well-being are generally enhanced.