Identification of novel exonic mobile element insertions in epithelial ovarian cancers.
Identification of novel exonic mobile element insertions in epithelial ovarian cancers.
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DOI：
10.1038/hgv.2015.30
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发表时间：
2015
影响因子：
1.5
通讯作者：
Inoue I
中科院分区：
文献类型：
--
作者：
Hayano T;Yamada S;Hosomichi K;Nakaoka H;Yoshihara K;Adachi S;Kashima K;Tanaka K;Enomoto T;Inoue I
可移动元件约占人类基因组的一半。三个活跃的移动元素家族(L1、Alu和Sva)可能导致癌症等疾病。我们使用外显子测序数据对44例上皮性卵巢癌进行了流动元件插入(MEI)分析。我们利用MOBSTER程序鉴定了106个MEI，其中8个是新的外显子MEI。
Mobile elements comprise about half of the human genome. Three active mobile element families (L1, Alu, and SVA) possibly cause diseases such as cancer. We conducted mobile element insertion (MEI) profiling of 44 epithelial ovarian cancers using exome-sequencing data. We identified a total of 106 MEIs using the Mobster program, 8 of which were novel exonic MEIs.