Oroxylin A maintains the colonic mucus barrier to reduce disease susceptibility by reconstituting a dietary fiber-deprived gut microbiota
Oroxylin A maintains the colonic mucus barrier to reduce disease susceptibility by reconstituting a dietary fiber-deprived gut microbiota
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Oroxylin A 通过重建缺乏膳食纤维的肠道微生物群来维持结肠粘液屏障，从而降低疾病易感性
DOI：
10.1016/j.canlet.2021.05.018
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发表时间：
2021-06-01
期刊：
影响因子：
9.7
通讯作者：
Lu, Na
中科院分区：
文献类型：
--
作者：
Bai, Dongsheng;Sun, Tifan;Lu, Na
膳食纤维的摄入有助于维持肠道稳态。纤维缺乏导致共生体利用粘蛋白作为能量来源来破坏粘液层，从而增加对炎症性肠病的易感性。在这里，我们报道了 Oroxylin A（一种天然黄酮类化合物）可以改善由纤维缺乏引起的低度结肠炎症，减轻结肠炎，并进一步预防小鼠中与结肠炎相关的结肠癌。 Oroxylin A 的抗炎作用是由于它改变了肠道微生物群。我们发现 Oroxylin A 显着增加了粪前列真杆菌的水平，并且定植的粪前列真杆菌显着预防小鼠结肠炎和结肠癌的发生。总之，我们在这项研究中的结果表明，oroxylin A 可能通过增加产粪真杆菌的水平来降低对肠道疾病的易感性，这可能为肠道疾病的治疗提供一种治疗替代方案。
Dietary fiber intake helps to maintain gut homeostasis. Fiber deficiency causes commensals to utilize mucins as an energy source to destroy mucus layer, thus promoting susceptibility to inflammatory bowel disease. Here, we reported that oroxylin A, a natural flavonoid, ameliorated low-grade colonic inflammation caused by fiber deficiency, alleviated colitis, and further prevented colitis-associated colon cancer in mice. The antiinflammatory effect of oroxylin A was due to its alteration of gut microbiota. We found that the levels of Eubacterium coprostanoligenes was significantly increased by oroxylin A and the colonized Eubacterium coprostanoligenes significantly protected against colitis and carcinogenesis in colon of mice. Together, our results in this study suggest that oroxylin A may reduce the susceptibility to intestinal diseases by increasing the level of Eubacterium coprostanoligenes which could provide a therapeutic alternation for the treatment of intestinal diseases.