Resting state cortical connectivity reflected in EEG coherence in individuals with autism
Resting state cortical connectivity reflected in EEG coherence in individuals with autism
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DOI：
10.1016/j.biopsych.2006.11.012
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发表时间：
2007-08-01
影响因子：
10.6
通讯作者：
Dawson, Geraldine
中科院分区：
文献类型：
--
作者：
Murias, Michael;Webb, Sara J.;Dawson, Geraldine
背景：自闭症谱系障碍 (ASD) 的理论概念和脑血流的实验研究表明 ASD 中分布式神经系统之间的连接存在异常。方法：通过 18 名 ASD 成人和 18 名处于闭眼静息状态的对照成年人中窄频带高密度电极阵列中的电极对之间的脑电对数相干性来评估功能连接。结果：在 θ (3-6 Hz) 频率范围内，局部相干性明显升高自闭症谱系障碍（ASD）组，尤其是左半球额叶和颞区。在较低的 alpha 范围（8-10 Hz）中，自闭症谱系障碍组在额叶区域内以及额叶与所有其他头皮区域之间的整体一致性明显降低。 ASD 组在 3 至 6 Hz 和 13-17 Hz 之间表现出显着较高的相对功率，而在 9 至 10 Hz 之间表现出显着较低的相对功率。结论：在闭眼静息状态下，ASD 受试者在不同的空间和时间尺度上表现出明显的过度连接和连接不足的鲁棒模式。
Background: Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD.Methods: Functional connectivity was assessed with electroencepha log ra phic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state.Results: In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz.Conclusions: Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.