The relationship of anthropometric measures to radiological features of the breast in premenopausal women.
The relationship of anthropometric measures to radiological features of the breast in premenopausal women.
复制标题
人体测量指标与绝经前女性乳腺的放射学特征的关系。
DOI：
10.1038/bjc.1998.660
复制
发表时间：
1998-11
影响因子：
8.8
通讯作者：
Tritchler, D L
中科院分区：
文献类型：
--
作者：
Boyd, N F;Lockwood, G A;Byng, J W;Little, L E;Yaffe, M J;Tritchler, D L
我们研究了273名绝经前妇女，她们在乳房x线照相术中有不同程度的乳腺实质密度，我们测量了她们的身高、体重和皮褶厚度。通过扫描密度计将乳房x光片数字化到高空间分辨率，并对图像进行分析以测量致密组织的面积和乳房的总面积。百分比密度和非致密组织的面积是根据这些测量计算出来的。我们发现乳房x光检查与体型有不同的关联。体重和肥胖的quette指数与乳腺非致密组织面积和乳腺总面积呈显著正相关，与致密组织面积呈显著负相关。我们还发现乳腺组织的密度和非密度之间有很强的反比关系。包含人体测量变量的统计模型在密集区域解释了高达8%的方差，但在非密集区域解释了高达49%的方差，在总面积中解释了43%的方差。这些结果表明，在乳腺癌的病因学研究中，使用乳房x线摄影密度应该分别考虑致密组织和非致密组织。除了百分比密度外，还应研究将这两种组织的信息结合起来的方法。
We studied 273 premenopausal women recruited from mammography units who had different degrees of density of the breast parenchyma on mammography, in whom we measured height, weight and skinfold thicknesses. Mammograms were digitized to high spatial resolution by a scanning densitometer and images analysed to measure the area of dense tissue and the total area of the breast. Per cent density and the area of non-dense tissue were calculated from these measurements. We found that the mammographic measures had different associations with body size. Weight and the Quetelet index of obesity were strongly and positively associated with the area of non-dense tissue and with the total area of the breast, but less strongly and negatively correlated with the area of dense tissue. We also found a strong inverse relationship between the areas of radiologically dense and non-dense breast tissue. Statistical models containing anthropometric variables explained up to 8% of the variance in dense area, but explained up to 49% of the variance in non-dense area and 43% of variance in total area. These results suggest that aetiological studies in breast cancer that use mammographic density should consider dense and non-dense tissues separately. In addition to per cent density, methods should be examined that combine information from these two tissues.