Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism.
Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism.
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脊髓损伤后的纤维化疤痕：与其他细胞的串扰、细胞起源、功能和机制。
DOI：
10.3389/fncel.2021.720938
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发表时间：
2021
影响因子：
5.3
通讯作者：
Jing J
中科院分区：
文献类型：
--
作者：
Li Z;Yu S;Hu X;Li Y;You X;Tian D;Cheng L;Zheng M;Jing J
脊髓损伤(SCI)后轴突再生失败导致永久性感觉运动功能丧失。瘢痕组织的持续存在，主要是纤维性瘢痕和星形细胞瘢痕，是轴突再生失败的关键原因，被广泛认为是脊髓损伤的治疗靶点。星形细胞瘢痕已被广泛研究，而纤维性瘢痕较少受到关注。在此，我们对脊髓损伤后纤维化瘢痕的形成及其与损伤核心中其他主要细胞成分的串扰以及其细胞来源、功能和机制的研究进展作一综述。本研究有望为纤维化瘢痕作为脊髓损伤的治疗靶点提供重要的依据和新的见解。
The failure of axonal regeneration after spinal cord injury (SCI) results in permanent loss of sensorimotor function. The persistent presence of scar tissue, mainly fibrotic scar and astrocytic scar, is a critical cause of axonal regeneration failure and is widely accepted as a treatment target for SCI. Astrocytic scar has been widely investigated, while fibrotic scar has received less attention. Here, we review recent advances in fibrotic scar formation and its crosstalk with other main cellular components in the injured core after SCI, as well as its cellular origin, function, and mechanism. This study is expected to provide an important basis and novel insights into fibrotic scar as a treatment target for SCI.
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影响因子：
29
作者：
Cai, Bishuang;Dongiovanni, Paola;Tabas, Ira
通讯作者：
Tabas, Ira
影响因子：
64.5
作者：
Dias DO;Kim H;Holl D;Werne Solnestam B;Lundeberg J;Carlén M;Göritz C;Frisén J
通讯作者：
Frisén J
纤连蛋白EDA在脊髓损伤后形成慢性纤维化疤痕。
影响因子：
6.1
作者：
Cooper JG;Jeong SJ;McGuire TL;Sharma S;Wang W;Bhattacharyya S;Varga J;Kessler JA
通讯作者：
Kessler JA
影响因子：
4.8
作者：
Bondjers, Cecilia;He, Liqun;Betsholtz, Christer
通讯作者：
Betsholtz, Christer
影响因子：
15.9
作者：
Hakuno, Daihiko;Kimura, Naritaka;Fukuda, Keiichi
通讯作者：
Fukuda, Keiichi