Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System
Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System
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Polycomb 抑制复合体 2：中枢神经系统中的新兴作用
DOI：
10.1177/1073858417747839
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发表时间：
2018-06-01
期刊：
影响因子：
5.6
通讯作者：
Liu, Chang-Mei
中科院分区：
文献类型：
--
作者：
Liu, Pei-Pei;Xu, Ya-Jie;Liu, Chang-Mei
多梳抑制复合物 2 (PRC2) 负责催化组蛋白 H3 在赖氨酸 27 (H3K27me2/3) 处的二甲基化和三甲基化。 PRC2 的亚基在中枢神经系统 (CNS) 中广泛表达。 PRC2 以及 H3K27me2/3 在神经元身份、神经干/祖细胞的增殖和分化、神经元形态和胶质生成中发挥独特的作用。 PRC2 亚基的突变或失调通常会导致神经系统疾病。因此，PRC2可能代表驱动神经退行性疾病的不同病理过程的共同靶标。更好地了解 CNS 中 PRC2 介导的复杂调控网络将有助于开发新的治疗方法并生成用于治疗神经系统疾病的特定脑细胞类型。
The polycomb repressive complex 2 (PRC2) is responsible for catalyzing both di- and trimethylation of histone H3 at lysine 27 (H3K27me2/3). The subunits of PRC2 are widely expressed in the central nervous system (CNS). PRC2 as well as H3K27me2/3, play distinct roles in neuronal identity, proliferation and differentiation of neural stem/progenitor cells, neuronal morphology, and gliogenesis. Mutations or dysregulations of PRC2 subunits often cause neurological diseases. Therefore, PRC2 might represent a common target of different pathological processes that drive neurodegenerative diseases. A better understanding of the intricate and complex regulatory networks mediated by PRC2 in CNS will help to develop new therapeutic approaches and to generate specific brain cell types for treating neurological diseases.