δ-aminolevulinic acid dehydratase (ALAD) polymorphism and susceptibility of workers exposed to inorganic lead and its effects on neurobehavioral functions
δ-aminolevulinic acid dehydratase (ALAD) polymorphism and susceptibility of workers exposed to inorganic lead and its effects on neurobehavioral functions
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DOI：
10.1016/j.neuro.2004.01.010
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发表时间：
2004-12-01
期刊：
影响因子：
3.4
通讯作者：
Chia, KS
中科院分区：
文献类型：
--
作者：
Chia, SE;Yap, E;Chia, KS
我们对一组男性工人进行了横断研究，以确定暴露于低至中等水平无机铅的中国、马来西亚和印度工人中6-氨基乙酰丙酸脱水酶（ALAD）多态性的频率。此外，我们还研究了ALAD1和ALAD2基因型与这些工人的神经行为功能之间的关系。研究对象为120名男性工人。采集每位工人的血液和尿液，以确定ALAD基因型、血铅水平、ALAD和尿δ -氨基乙酰丙酸（ALAU）。ALAD1-1基因型是三个族群的优势基因型，ALAD2-2基因型最为罕见。与华人（3.6%）相比，马来人（16.7%）和印度人（14.3%）的aldi -2分布更高。选用了世界卫生组织神经行为核心测试组（WHO-NCTB）的部分测试。虽然ALAD1-1和ALAD1-2/2-2组的工人血铅水平相当，但与ALAD1-2/2-2基因型的工人（13名工人）相比，106名携带ALAD1-1基因型的工人尿ALA明显较高，涉及运动灵活性的神经行为评分明显较差。假设ALAD2等位基因可能对铅的神经毒性作用起保护作用。要证实这一假设，还需要对携带ALAD2等位基因的工人进行更大规模的研究。(C) 2004爱思唯尔公司版权所有。
We carried out a cross-sectional study on a group of male workers to determine the frequency of 6-aminolevulinic acid dehydratase (ALAD) polymorphisms among Chinese, Malays and Indians workers who were exposed to low to medium levels of inorganic lead. Also, the association between ALAD1 and ALAD2 genotypes and neurobehavioral functions among these workers were investigated. A total of 120 male workers were studied. Blood and urine were collected for each worker to determine the ALAD genotypes, blood lead levels, ALAD, and urinary delta-aminolevulinic acid (ALAU). ALAD1-1 was the predominant genotype for all three ethnic groups while ALAD2-2 was the rarest. The distribution of ALADI-2 was higher among Malays (16.7%) and Indians (14.3%), compared to Chinese (3.6%). Selected tests from the World Health Organization Neurobehavioral Core Test Battery (WHO-NCTB) were used. Although workers in the ALAD1-1 and ALAD1-2/2-2 groups had comparable blood lead levels, the 106 workers with ALAD1-1 genotypes have significantly higher urinary ALA and significantly poorer neurobehavioral scores involving motor dexterity compared with those who have ALAD1-2/2-2 genotypes (13 workers). It is postulated that the ALAD2 allele may exert protective measures against the neurotoxic effects of lead. Further study involving a larger cohort of workers with the ALAD2 allele would be needed to confirm this hypothesis. (C) 2004 Elsevier Inc. All rights reserved.