The renal renin-angiotensin system
The renal renin-angiotensin system
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DOI：
10.1152/advan.00049.2009
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发表时间：
2009-12-01
影响因子：
2.1
通讯作者：
Harrison-Bernard, Lisa M.
中科院分区：
文献类型：
--
作者：
Harrison-Bernard, Lisa M.
哈里森-伯纳德LM。肾脏的肾素-血管紧张素系统。Adv Physiol Educ 33：270-274，2009; doi：10.1152/20.00049.2009.肾素-血管紧张素系统（RAS）是钠平衡、细胞外液量、血管阻力以及最终动脉血压的关键调节器。在肾脏中，血管紧张素II通过肾血流和肾小球滤过率的血液动力学控制以及肾小管上皮细胞氯化钠和水转运机制的组合发挥其保护盐和水的作用。RAS作用的药理学抑制广泛用于治疗高血压、充血性心力衰竭、左心室功能障碍、肺和全身性水肿、糖尿病肾病、肝硬化、硬皮病和偏头痛患者。因此，对RAS对正常肾脏生理的影响的透彻理解对于一年级医学生来说是非常重要的。
Harrison-Bernard LM. The renal renin-angiotensin system. Adv Physiol Educ 33: 270-274, 2009; doi: 10.1152/advan.00049.2009. The renin-angiotensin system (RAS) is a critical regulator of sodium balance, extracellular fluid volume, vascular resistance, and, ultimately, arterial blood pressure. In the kidney, angiotensin II exerts its effects to conserve salt and water through a combination of the hemodynamic control of renal blood flow and glomerular filtration rate and tubular epithelial cell sodium chloride and water transport mechanisms. Pharmacological inhibition of the actions of the RAS are widely used in the treatment of patients with hypertension, congestive heart failure, left ventricular dysfunction, pulmonary and systemic edema, diabetic nephropathy, cirrhosis of the liver, scleroderma, and migraines. Therefore, a thorough understanding of the influences of the RAS on normal renal physiology is of major importance for first-year medical students.