Ten Hotspot MicroRNAs and Their Potential Targets of Chondrocytes Were Revealed in Osteoarthritis Based on Bibliometric Analysis.
Ten Hotspot MicroRNAs and Their Potential Targets of Chondrocytes Were Revealed in Osteoarthritis Based on Bibliometric Analysis.
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基于文献计量分析，在骨关节炎中揭示了十个热点microRNA及其潜在的软骨细胞的潜在靶标。
DOI：
10.1155/2022/8229148
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发表时间：
2022
影响因子：
--
通讯作者：
Wu, Qiao-Feng
中科院分区：
文献类型：
--
作者：
Hu, Wei-Shang;Zhang, Qi;Li, Si-Hui;Ai, Shuang-Chun;Wu, Qiao-Feng
骨关节炎（OA）是最常见的关节疾病和衰弱性疾病之一。目前的证据表明，microRNAs（miRNAs）在OA的发病机制中起着关键作用，并有很大的潜力作为新的生物标志物和治疗靶点。通过CiteSpace和VOSviewer分析OA中miRNAs的研究动态和研究现状，进一步展示OA中的热点miRNAs。 关于miRNA和OA的出版物于2021年10月30日从Web of Science（WOS）数据库中提取。我们评估了出版物，机构，国家，作者，期刊，引用参考文献和关键词的数量与软件工具CiteSpace和VOSviewer的帮助下。 共纳入1109篇文章。与miRNAs和OA相关的研究从2008年开始出现，总体趋势是增加的。我国科研机构在论文数量上具有领先优势，但缺乏高质量、高被引的研究，在共引文献方面落后。基于文献计量学分析，10种miRNAs包括miR-140、miR-146、miR-34、miR-181、miR-27、miR-9、miR-29、miR-21、miR-26和miR-155和软骨细胞被揭示为最明显的miRNAs和OA的潜在靶点。今后将更多地关注miRNAs调控软骨细胞的研究，这可能会加速未来可能的诊断生物标志物和OA诊断生物标志物的发现。
Osteoarthritis (OA) is one of the most common joint disorders and debilitating diseases. Current evidence suggests that microRNAs (miRNAs) play a critical role in the pathogenesis of OA and have great potential as new biomarkers and therapeutic targets. We aimed to analyze the trends and research status on miRNAs in OA and further demonstrate the hotspot miRNAs in OA via CiteSpace and VOSviewer. Publications regarding miRNAs and OA were extracted from the Web of Science (WOS) database on October 30, 2021. We assessed the number of publications, institutions, countries, authors, journals, cited references, and keywords with the help of the software tools CiteSpace and VOSviewer. A total of 1109 articles were included. Research related to miRNAs and OA began to appear in 2008, and the overall trend is increasing. Chinese institutions have a leading advantage in the number of publications but lack high-quality and high-cited research and are laggard in co-cited literature. Ten miRNAs including miR-140, miR-146, miR-34, miR-181, miR-27, miR-9, miR-29, miR-21, miR-26, and miR-155 and chondrocytes were revealed as the most obvious miRNAs and a potential target for OA based on bibliometric analysis. More focus will be placed on a comprehensive study on chondrocytes regulated by miRNAs, which may accelerate possible diagnostic biomarkers and diagnostic biomarkers of OA in the future.
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影响因子：
7
作者：
D'Adamo S;Alvarez-Garcia O;Muramatsu Y;Flamigni F;Lotz MK
通讯作者：
Lotz MK
影响因子：
3.7
作者：
Chen, Chaomei;Song, Min
通讯作者：
Song, Min
影响因子：
5.4
作者：
Jin L;Zhao J;Jing W;Yan S;Wang X;Xiao C;Ma B
通讯作者：
Ma B
影响因子：
2.3
作者：
Díaz-Prado S;Cicione C;Muiños-López E;Hermida-Gómez T;Oreiro N;Fernández-López C;Blanco FJ
通讯作者：
Blanco FJ
DOI：
10.1016/j.biocel.2017.12.003
发表时间：
2018-01-01
影响因子：
4
作者：
Hu, Jialei;Wang, Zi;Jia, Li
通讯作者：
Jia, Li