DETECTION OF ANTIBODIES AGAINST THE CELLULAR PROTEIN P53 IN SERA FROM PATIENTS WITH BREAST-CANCER
DETECTION OF ANTIBODIES AGAINST THE CELLULAR PROTEIN P53 IN SERA FROM PATIENTS WITH BREAST-CANCER
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DOI：
10.1002/ijc.2910300404
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发表时间：
1982-01-01
影响因子：
6.4
通讯作者：
BULBROOK, RD
中科院分区：
文献类型：
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作者：
CRAWFORD, LV;PIM, DC;BULBROOK, RD
在原发性或继发性乳腺癌患者血清中发现了与宿主蛋白p53反应的抗体。155例乳腺癌患者血清中有14例抗p53抗体阳性（9%），164例正常妇女对照血清中未检测到阳性。血清阳性患者首次转移的位置不常见，肺转移多于预期，骨转移少于预期。抗p53抗体的检测表明，p53在乳腺肿瘤中的量、类型或呈递方式发生了改变，从而使其具有免疫原性。
Antibodies reacting with the host protein p53 were found in the sera of patients with primary or secondary carcinoma of the breast. Fourteen of the 155 sera from breast cancer patients tested were positive for anti p53 antibodies (9%) and no positives were detected among 164 control sera from normal women tested. The locations of the 1st metastasis in patients with positive sera were unusual, with more lung metastases and fewer bone metastases than expected. The detection of anti-p53 antibodies indicates that p53 is altered in amount, type or presentation in breast tumors so that it becomes immunogenic.