ARFI variance of acceleration (VoA) for noninvasive characterization of human carotid plaques in vivo.
ARFI variance of acceleration (VoA) for noninvasive characterization of human carotid plaques in vivo.
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DOI：
10.1109/embc.2017.8037484
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发表时间：
2017-07
期刊：
影响因子：
--
通讯作者：
Gallippi CM
中科院分区：
文献类型：
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作者：
Torres G;Czernuszewicz TJ;Homeister JW;Farber MA;Gallippi CM
评估斑块结构和组成与识别斑块破裂和下游缺血事件的风险相关，而不是狭窄程度。使用声辐射力脉冲(ARFI)超声成像对颈动脉斑块的结构和成分进行了无创评估。特别是，ARFI得出的峰值位移(PD)估计已被证明可以区分软斑块(富脂坏死核(LRNC)或斑块内出血(IPH))和僵硬(胶原(Col)或钙(CAL))斑块特征；然而，PD不能区分LRNC与IPH或COL与CAL。这项研究的目的是评估一种新的基于ARFI的测量方法，即加速度方差(VOA)，用于区分软斑块和硬斑块成分。PD和VOA的结果都是活体获得的人类颈动脉斑块的结果，并与病理学家分析的组织学标准相匹配。与PD相比，VOA的斑块特征对比度平均增加了60%。
Rather than degree of stenosis, assessing plaque structure and composition is relevant to discerning risk for plaque rupture with downstream ischemic event. The structure and composition of carotid plaque has been assessed noninvasively using Acoustic Radiation Force Impulse (ARFI) ultrasound imaging. In particular, ARFI-derived peak displacement (PD) estimations have been demonstrated for discriminating soft (lipid rich necrotic core (LRNC) or intraplaque hemorrhage (IPH)) from stiff (collagen (COL) or calcium (CAL)) plaque features; however, PD did not differentiate LRNC from IPH or COL from CAL. The purpose of this study is to evaluate a new ARFI-based measurement, the variance of acceleration (VoA), for differentiating among soft and stiff plaque components. Both PD and VoA results were obtained in vivo for a human carotid plaque acquired in a previous study and matched to a histological standard analyzed by a pathologist. With VoA, plaque feature contrast was increased by an average of 60% in comparison to PD.