Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature.
Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature.
复制标题
创伤性脑损伤中创伤后应激障碍的神经影像学相关性：文献的系统回顾。
DOI：
10.1089/neu.2021.0453
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发表时间：
2023
影响因子：
4.2
通讯作者：
Roper
中科院分区：
文献类型：
--
作者：
Esagoff,AaronI;Stevens,DanielA;Kosyakova,Natalia;Woodard,Kaylee;Jung,Diane;Richey,LisaN;Daneshvari,NicholasO;Luna,LiciaP;Bray,MichaelJC;Bryant,BarryR;Rodriguez,CarlaP;Krieg,Akshay;Trapp,NicholasT;Jones,MelissaB;Roper
神经影像学广泛用于研究创伤性脑损伤（TBI）和创伤后应激障碍（PTSD）。 TBI 后发生 PTSD 的风险高于非 TBI 创伤后的风险，并且 PTSD 与 TBI 后更差的结果相关。研究 TBI 相关 PTSD 的神经影像相关性可能有助于深入了解这两种疾病的病因，并有助于识别那些最有可能出现持续症状的 TBI 患者。本系统综述的目的是检查当前关于 TBI 相关 PTSD 神经影像学的文献，总结主要发现，并强调其优势和局限性以指导未来的研究。 2022 年 1 月之前，在 PubMed (MEDLINE®)、PsycINFO、Embase 和 Scopus 数据库中进行了符合系统评价和荟萃分析方案 (PRISMA) 的首选报告项目文献检索。数据库查询产生了 4486 篇文章，根据指定的纳入标准将其缩小到最终的 16 项研究队列，由 854 名 TBI 参与者组成。纳入的文章中，关于 TBI 相关 PTSD 的神经影像学相关性尚未达成共识。少数研究表明，TBI 相关的 PTSD 与白质束变化（尤其是额颞叶区域）以及静息状态连接的全脑网络的变化有关。希望确定与 TBI 相关 PTSD 可靠的神经影像相关性的未来研究将受益于确保一致的病例定义，最好是临床医生诊断的 TBI 和 PTSD、选择可比较的对照组以及注意受伤后的影像学时机。需要进行前瞻性研究，其目的应是进一步区分诱发因素和 TBI 相关 PTSD 的后遗症。
Neuroimaging is widely utilized in studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD). The risk for PTSD is greater after TBI than after non-TBI trauma, and PTSD is associated with worse outcomes after TBI. Studying the neuroimaging correlates of TBI-related PTSD may provide insights into the etiology of both conditions and help identify those TBI patients most at risk of developing persistent symptoms. The objectives of this systematic review were to examine the current literature on neuroimaging in TBI-related PTSD, summarize key findings, and highlight strengths and limitations to guide future research. A Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) compliant literature search was conducted in PubMed (MEDLINE®), PsycINFO, Embase, and Scopus databases prior to January 2022. The database query yielded 4486 articles, which were narrowed based on specified inclusion criteria to a final cohort of 16 studies, composed of 854 participants with TBI. There was no consensus regarding neuroimaging correlates of TBI-related PTSD among the included articles. A small number of studies suggest that TBI-related PTSD is associated with white matter tract changes, particularly in frontotemporal regions, as well as changes in whole-brain networks of resting-state connectivity. Future studies hoping to identify reliable neuroimaging correlates of TBI-related PTSD would benefit from ensuring consistent case definition, preferably with clinician-diagnosed TBI and PTSD, selection of comparable control groups, and attention to imaging timing post-injury. Prospective studies are needed and should aim to further differentiate predisposing factors from sequelae of TBI-related PTSD.