A review on prescribing patterns of antihypertensive drugs.
A review on prescribing patterns of antihypertensive drugs.
复制标题
DOI：
10.1186/s40885-016-0042-0
复制
发表时间：
2015
影响因子：
4.2
通讯作者：
Peela LT
中科院分区：
文献类型：
--
作者：
Jarari N;Rao N;Peela JR;Ellafi KA;Shakila S;Said AR;Nelapalli NK;Min Y;Tun KD;Jamallulail SI;Rawal AK;Ramanujam R;Yedla RN;Kandregula DK;Argi A;Peela LT
高血压仍然是一个重要的公共卫生问题，因为它的发病率、死亡率和对社会的经济影响。它是心血管、脑血管和肾脏并发症的重要危险因素。据估计，到2025年，将有15.6亿人患有高血压。高血压患病率的增加和治疗费用的持续增加影响了医生的处方模式和患者的治疗依从性。已经出版了一些关于高血压管理的国家和国际指南。多年来，利尿剂一直被认为是治疗高血压的一线药物；然而，最近国家联合委员会的指南(JNC8指南)建议除了利尿剂外，还应同时使用钙通道阻滞剂和血管紧张素转换酶抑制剂作为一线药物。抗高血压药物组合通常用于有效的长期治疗和治疗合并症。本文综述了抗高血压药物的使用情况、成本因素、患者对治疗的依从性以及医生在不同环境下(包括印度情景)开药时对指南的遵守情况。抗高血压药物处方模式研究有助于监测、评估和必要地修改处方习惯，以实现合理和低成本的治疗。此外，定期更新建议的指南和创新药物配方，以及处方监测研究有助于合理使用抗高血压药物，这些药物可以根据患者的要求进行量身定做，包括发展中国家的患者。
Hypertension continues to be an important public health concern because of its associated morbidity, mortality and economic impact on the society. It is a significant risk factor for cardiovascular, cerebrovascular and renal complications. It has been estimated that by 2025, 1.56 billion individuals will have hypertension. The increasing prevalence of hypertension and the continually increasing expense of its treatment influence the prescribing patterns among physicians and compliance to the treatment by the patients. A number of national and international guidelines for the management of hypertension have been published. Since many years ago, diuretics were considered as the first-line drugs for treatment of hypertension therapy; however, the recent guidelines by the Joint National Commission (JNC8 guidelines) recommend both calcium channel blockers as well as angiotensin-converting enzyme inhibitors as first-line drugs, in addition to diuretics. Antihypertensive drug combinations are generally used for effective long-term management and to treat comorbid conditions. This review focuses on the antihypertensive medication utilization, their cost factors, adherence to treatment by patients, and physicians’ adherence to guidelines in prescribing medications in different settings including Indian scenario. The antihypertensive medication prescribing pattern studies help in monitoring, evaluation and necessary modifications to the prescribing habits to achieve rational and cost-effective treatment. Additionally, periodic updating of recommended guidelines and innovative drug formulations, and prescription monitoring studies help in rational use of antihypertensive drugs, which can be tailored to suit the patients' requirements, including those in the developing countries.