Immune-related key gene CLDN10 correlates with lymph node metastasis but predicts favorable prognosis in papillary thyroid carcinoma
Immune-related key gene CLDN10 correlates with lymph node metastasis but predicts favorable prognosis in papillary thyroid carcinoma
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免疫相关关键基因 CLDN10 与淋巴结转移相关，但可预测甲状腺乳头状癌的良好预后
DOI：
10.18632/aging.102780
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发表时间：
2020-02-15
期刊：
影响因子：
5.2
通讯作者：
Zhuo, Xianlu
中科院分区：
文献类型：
--
作者：
Xiang, Zhaolan;Zhong, Cheng;Zhuo, Xianlu
免疫细胞在淋巴结转移（LNM）中的功能引起了人们的广泛关注。本研究旨在筛选PTC中关键的免疫相关和LNM相关基因。在发现阶段，利用生物信息学方法筛选LNM中的免疫相关基因。在验证阶段，基因与 LNM 的关联首先在癌症基因组图谱的队列和基于组织芯片的队列中得到证实。然后，进一步探讨基因与免疫细胞浸润的关系。因此，CLDN10 被鉴定出来，其高表达与 PTC 中 LNM 的存在相关，但预示着良好的预后。 CLDN10的高表达与B细胞、CD8+T细胞和巨噬细胞等多种免疫细胞的浸润呈正相关。 CLDN10 高表达可能通过增加免疫细胞浸润来改善 PTC 患者的预后，尽管它可能与 LNM 相关。总之，虽然CLDN1可能与LNM相关，但它也可能增加免疫细胞（包括CD8+T细胞和巨噬细胞）的浸润，并改善PTC患者的临床结果。预后评估需要考虑肿瘤纯度和免疫细胞浸润的影响。
The functions of immune cells in lymph node metastasis (LNM) have attracted considerable attention. This study aimed to screen the key immune-related and LNM-related genes in PTC. In the discovery phase, the immune-related genes in LNM were screened by using bioinformatics methods. In the validation phases, the association of the genes with LNM was first confirmed in a cohort from The Cancer Genome Atlas and a cohort based on a tissue chip. Then, the relationship of the genes with immune cell infiltration was further explored. Consequently, CLDN10 was identified, and its high expression was correlated with the presence of LNM in PTC but predicted a favorable prognosis. High CLDN10 expression was positively correlated with the infiltration of several immune cells, such as B cells, CD8+T cells, and macrophages. High CLDN10 expression may improve the outcomes of patients with PTC by increasing immune cell infiltration, although it might be associated with LNM. In conclusion, although CLDN1 might be correlated with LNM, it may also increase the infiltration of immune cells, including CD8+T cells and macrophages, and improve the clinical outcomes of patients with PTC. The effects of tumor purity and immune cell infiltration need to be considered in prognosis evaluation.