A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults
A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults
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DOI：
10.1159/000492497
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发表时间：
2018-01-01
影响因子：
2.6
通讯作者：
Mirzaei, Khadijeh
中科院分区：
文献类型：
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作者：
Pooyan, Sara;Rahimi, Mohammad Hossein;Mirzaei, Khadijeh
背景资料：最近的研究表明，抑郁症与高蛋白低脂肪摄入呈负相关，与维生素D结合蛋白（VDBP）呈正相关。因此，本研究的目的是检查蛋白质/脂肪饮食模式和VDBP基因型之间的相互作用，在表面健康的成年人谁没有被诊断为任何慢性疾病的抑郁症的风险。研究方法：在这项研究中，265人（126名男性和139名女性），年龄在18-55岁，从中部和西部德黑兰社区的基础上方便抽样招募。使用身体成分分析仪测量身体成分，并使用抑郁焦虑压力量表21（DASS-21）问卷将抑郁症状分为正常，中度抑郁或重度抑郁。通过半定量食物频率问卷确定饮食模式，以评估12个月期间的典型食物摄入量。采集所有参与者的血液样本，并对所有参与者进行生化测量。采用聚合酶链反应-限制性片段长度多态性分析方法，对编码VDBP的GC基因的两个多态性（rs7041和rs 4588）进行了分析。结果如下：将参与者分为三组后，发现抑郁症与饮食之间存在统计学显着相关性（p = 0.03）：高蛋白/低脂肪（HP/LF）组、中蛋白/中脂肪（MP/MF）组和低蛋白/高脂肪（LP/HF）组。此外，研究结果表明，抑郁症与rs7041和rs 4588多态性相关（分别为p = 0.05和p = 0.02）。接下来，我们使用多项逻辑模型来研究抑郁症的风险。在中度和重度抑郁组中，HP/LF饮食与rs7041多态性之间观察到显著的相互作用（分别为β =-0.30，p = 0.05和β =-0.48，p = 0.01）。结论：这项研究表明，HP/LF饮食与rs7041多态性相互作用，T等位基因携带者中度和重度抑郁症的患病率更高。(C)2018 S. Karger AG，巴塞尔
Background: Recent studies have shown that depression is inversely correlated with high protein and low fat intake and positively correlated with vitamin D-binding protein (VDBP). Therefore, the aim of this study was to examine the interaction between protein/fat dietary patterns and VDBP genotypes with regard to the risk of depression in apparently healthy adults who have not been diagnosed with any chronic disease. Methods: In this study, 265 individuals (126 males and 139 females) aged 18-55 years were recruited from the communities of central and west Tehran based on convenience sampling. Body composition was measured with a body composition analyzer and depression symptoms were categorized as normal, moderate depression, or severe depression using the Depression Anxiety Stress Scales 21 (DASS-21) questionnaire. Dietary patterns were determined by a semiquantitative food frequency question-naire to assess typical food intake during the 12-month period. Blood samples were collected from and biochemical measurements performed on all participants. An analysis of two polymorphisms (rs7041 and rs4588) in the GC gene, which encodes VDBP, was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: A statistically significant association was found between depression and diet (p = 0.03) after having categorized the participants into three groups: a high-protein/low-fat (HP/LF) group, a moderate-protein/moderate-fat (MP/MF) group, and a low-protein/high-fat (LP/HF) group. Moreover, the findings demonstrated that depression was related to both the rs7041 and the rs4588 polymorphism (p = 0.05 and p = 0.02, respectively). We next used multinomial logistic modeling to investigate the risk of depression. A significant interaction was observed between HP/LF diet and the rs7041 polymorphism in the moderate-and severe-depression groups (beta = -0.30, p = 0.05, and beta = -0.48, p = 0.01, respectively). Conclusion: This study showed that an HP/LF diet interacts with the rs7041 polymorphism, with T allele carriers having a greater prevalence of moderate and severe depression. (C) 2018 S. Karger AG, Basel